Board Certification and Academic Information
||Internal Medicine - Research Associate Professor
Dermatology - Adjunct Associate Professor
||American Board of Internal Medicine (Sub: Infec Disease)
American Board of Internal Medicine (Internal Medicine)
National Board of Medical Examiners
Academic Office Locations
|Academic Office Phone Number
||Academic Office Address
||School of Medicine
30 N 1900 E
Salt Lake City, UT 84132
Dr. John Kriesel graduated from Lake Forest High School in 1980 and then cum laude from the University of Illinois in 1984. He went on to graduate from Washington University Medical School in 1988. He came to Utah that year and completed a residency in Internal Medicine in 1991, and then a fellowship in Infectious Diseases in 1994. Dr. Kriesel joined the faculty at the University of Utah School of Medicine in 1996 with a primary appointment in Internal Medicine and Infectious Diseases. He was promoted to Research Associate Professor in 2007. He is currently board certified in Infectious Diseases.
Dr. Kriesel's primary interests here are in translational and clinical reseach. His esearch projects involve the genetics of human cold sores, possible microbial triggers of multiple sclerosis, and strategies for the treatment of herpes simplex virus infections including vaccination and novel pharmaceuticals. He has authored 44 original scientific papers and book chapters, has 2 U.S. patents, several active research awards, and many completed research awards.
Dr. Kriesel's clinical responsibilities include infectious disease consultations at the VA and University Hospitals, internal medicine attending at the Salt Lake VA Hospital, HIV clinic at the University Hospital and the Utah State Prison, and clinical attending at the Salt Lake City STD Clinic. He participates in the education of nurses, dentists, graduate students, medical students, internal medicine residents, and infectious disease fellows.
Viral Trigger of MS:
Objectives: This is an exploratory (R21) application that uses advanced sequencing technology for the discovery of viruses in the brains of patients who died with primary progressive multiple sclerosis (PPMS).
Research Design: This is a retrospective study that utilizes frozen brain tissue from subjects with PPMS, other neurologic disease (OND), and normal controls. Deep sequencing of these specimens will be performed in the sequencing core laboratory at the Huntsman Cancer Institute on the University of Utah campus. Advanced informatics (metagenomics) will be used to compare millions of sequences from each group. The University of Utah Health Sciences IRB (UU-IRB #00028658) has reviewed the project and determined that the project uses only tissues from deceased, not living, subjects and is, therefore, exempt from review and oversight under NIH guidelines.
Methodology: The first specific aim will evaluate the presence, quantity, and assembly of virus-like sequences in brain specimens from primary progressive MS patients compared with control brain specimens. It is proposed that 15 PPMS frozen brain specimens will be extracted, evaluated, and sequenced using the techniques described. These sequences will be compared with the sets of control brain specimens, 15 each, from pathologically proven normal and OND controls. Differences in the presence and quantity of plausibly viral sequences between the MS and the two sets of control specimens will be examined using methods described below. The second aim of the project is to interrogate additional MS samples for the presence of candidate viruses using PCR. Additional samples will be interrogated for presence of the existing candidate virus, GBV-C, and any other candidate viruses that emerge from the proposed deep sequencing. This will be accomplished using the sequencing data to design primers and amplify any additional candidates that may emerge from the sequencing efforts in Aim 1. These PCR techniques will be applied to the 45 PPMS and control specimens sequenced in Aim 1. Additional cerebrospinal fluid (CSF), frozen brain specimens, and fixed paraffinized brain specimens from deceased, deidentified subjects will be collected for analysis.
Findings: The project is set to begin in the fall of 2011 so there are no new findings to report.
Clinical Relationships: This is a high risk, potentially high reward research project that is intended to identify one or more pathogens associated with PPMS, a devastating disease with no known cause and few effective options for treatment. If successful, this work could lead to treatment and/or prevention of PPMS in veterans and active duty military personnel.