J. Michael McIntosh,
MD
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Languages Spoken: English
Dr. McIntosh graduated from the University of California at Los Angeles Medical School, completed residency training at the University of Colorado and is board-certified in general adult psychiatry. He is Professor with tenure in the Department of Psychiatry and Research Professor in the Department of Biology. Dr. McIntosh is also the Medical Director of the Behavioral Health Clinic where he sees medically complex patients with co-morbid psychiatric conditions. He is ranked by US News and World Reports among the top 1% of doctors in the United States.
Clinical Locations
Psychiatry
801-581-7951
Specialties
Board Certification and Academic Information
| Academic Departments | Psychiatry
-
Professor Biology - Research Professor |
| Academic Divisions | Adult Psychiatry |
| Board Certification | American Board of Psychiatry & Neurology (Psychiatry) |
Dr. McIntosh graduated from the University of California at Los Angeles Medical School, completed residency training at the University of Colorado and is board-certified in general adult psychiatry. He is Professor with tenure in the Department of Psychiatry and Research Professor in the Department of Biology. Dr. McIntosh is also the Medical Director of the Behavioral Health Clinic where he sees medically complex patients with co-morbid psychiatric conditions. He is ranked by US News and World Reports among the top 1% of doctors in the United States.
Academic Locations
Biology Building
801-585-3622
School of Medicine
801-581-7951
Board Certification and Academic Information
| Academic Departments | Psychiatry
-
Professor Biology - Research Professor |
| Academic Divisions | Adult Psychiatry |
| Board Certification | American Board of Psychiatry & Neurology (Psychiatry) |
Research Interests
- Structure and function of neuronal nicotinic acetylcholine receptors
Education History
| Residency | University of Utah School of Medicine Psychiatry Resident |
| Residency | University of Colorado at Denver and Health Sciences Center Psychiatry Resident |
| Internship | University of Colorado at Denver and Health Sciences Center Psychiatry Intern |
| Professional Medical | University of California - Los Angeles Medicine M.D. |
| Undergraduate | University of Utah Biology B.S. |
Selected Publications - Journal Articles
Journal Article
- van Hout M, Valdes A, Christensen SB, Tran PT, Watkins M, Gajewiak J, Jensen AA, Olivera BM, McIntosh JM (2019). α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors. Neuropharmacology, 157, 107691.
- Peng C, Yan Y, Kim VJ, Engle SE, Berry JN, McIntosh JM, Neve RL, Drenan RM (2018). Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission. Eur J Neurosci, 50(3), 2224-2238.
- Hone AJ, Fisher F, Christensen S, Gajewiak J, Larkin D, Whiteaker P, McIntosh JM (2019). PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors. J Med Chem, 62(13), 6262-6275.
- Zakrzewicz A, Richter K, Zakrzewicz D, Siebers K, Damm J, Agn A, Hecker A, McIntosh JM, Chamulitrat W, Krasteva-Christ G, Manzini I, Tikkanen R, Padberg W, Janciauskiene S, Grau V (2019). SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player. Front Immunol, 10, 664.
- Grau V, Richter K, Hone AJ, McIntosh JM (2019). Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes. Front Pharmacol, 9, 1499.
- Arribas-Blzquez M, Olivos-Or LA, Barahona MV, Snchez de la Muela M, Solar V, Jimnez E, Gualix J, McIntosh JM, Ferrer-Montiel A, Miras-Portugal MT, Artalejo AR (2019). Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci, 20(1).
- Bavo F, Pucci S, Fasoli F, Lammi C, Moretti M, Mucchietto V, Lattuada D, Viani P, De Palma C, Budriesi R, Corradini I, Dowell C, McIntosh JM, Clementi F, Bolchi C, Gotti C, Pallavicini M (2018). Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan. J Med Chem, 61(23), 10531-10544.
- Hone AJ, Talley TT, Bobango J, Huidobro Melo C, Hararah F, Gajewiak J, Christensen S, Harvey PJ, Craik DJ, McIntosh JM (2018). Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors. J Biol Chem, 293(46), 17838-17852.
- Donvito G, Muldoon PP, Jackson KJ, Ahmad U, Zaveri NT, McIntosh JM, Chen X, Lichtman AH, Damaj MI (2018). Neuronal nicotinic acetylcholine receptors mediate ∆9 -THC dependence: Mouse and human studies. (Epub ahead of print) Addict Biol.
- Chen DJ, Gao FF, Ma XK, Shi GG, Huang YB, Su QX, Sudweeks S, Gao M, Dharshaun T, Eaton JB, Chang YC, Mcintosh JM, Lukas RJ, Whiteaker P, Steffensen SC, Wu J (2018). Pharmacological and functional comparisons of α6/α3β2β3-nAChRs and α4β2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line. Acta Pharmacol Sin, 39(10), 1571-1581.
- Richter K, Koch C, Perniss A, Wolf PM, Schweda EKH, Wichmann S, Wilker S, Magel I, Sander M, McIntosh JM, Padberg W, Grau V (2018). Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1β Release by Pulmonary Epithelial Cells. Molecules, 23(8).
- Richter K, Sagawe S, Hecker A, Kllmar M, Askevold I, Damm J, Heldmann S, Phlmann M, Ruhrmann S, Sander M, Schlter KD, Wilker S, Knig IR, Kummer W, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz AT, Koch C, Grau V (2018). C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation. Front Immunol, 9, 1604.
- Yan Y, Peng C, Arvin MC, Jin XT, Kim VJ, Ramsey MD, Wang Y, Banala S, Wokosin DL, McIntosh JM, Lavis LD, Drenan RM (2017). Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission. Cell Rep, 23(8), 2236-2244.
- Siebers K, Fink B, Zakrzewicz A, Agn A, Richter K, Konzok S, Hecker A, Zukunft S, Kllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V (2018). Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1β via CD36 and Nicotinic Acetylcholine Receptors. Front Immunol, 9, 877.
- Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM, McIntosh JM (2017). Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proc Natl Acad Sci U S A, 114(10), E1825-E1832.
- Pang X, Liu L, Ngolab J, Zhao-Shea R, McIntosh JM, Gardner PD, Tapper AR (2016). Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors. Neuropharmacology, 107, 294-304.
- Baladi MG, Nielsen SM, McIntosh JM, Hanson GR, Fleckenstein AE (2016). Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. Behav Pharmacol, 27(5), 422-30.
- Zhang D, McGregor M, Bordia T, Perez XA, McIntosh JM, Decker MW, Quik M (2015). α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage. Mov Disord, 30(14), 1901-1911.
Patent
- Maren Watkins, Baldomero M. Olivera, David R. Hillyard, J. Michael McIntosh, Robert M. Jones (2013). Alpha-conotoxin Peptides. U.S. Patent No. 8487075. Washington, D.C.:U.S. Patent and Trademark Office.
- J. Michael MCINTOSH, Baldomero M. OLIVERA, Michael ELLISON, Michelle A. VINCLER (2012). CONOTOXIN PEPTIDES. U.S. Patent No. 20120220539. Washington, D.C.:U.S. Patent and Trademark Office.
- J. Michael McIntosh (2012). ALPHA-CONOTOXIN MII ANALOGS. U.S. Patent No. 20120122803. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM (2012). Alpha-conotoxin Peptides. U.S. Patent No. US 8110549 B2. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh, JM (2012). Alpha-conotoxin Analogs. U.S. Patent No. US 8101,573 B2. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh, JM (2011). Alpha-conotoxin Peptides. U.S. Patent No. US 7902153 B. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM (2008). ¿-Conotoxin MII analogues. U.S. Patent No. U.S. Patent 7,387,997. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM (2008). Conotoxin peptides. U.S. Patent No. U.S. Patent 7,368,432. Washington, D.C.:U.S. Patent and Trademark Office.
- Watkins M, Olivera BM, Hillyard DR, McIntosh JM, Jones RM (2007). Alpha-conotoxin peptides. U.S. Patent No. United States Patent 7279549. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, McIntosh JM, Yoshikami D, Cartier GE, Luo S (2005). Uses of .alpha.-conotoxin peptide. U.S. Patent No. 6,958,323. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, Layer RT, McIntosh JM, Nielsen JS, Jones RM (2005). .alpha.-conotoxin peptides. U.S. Patent No. 6,855,805. Washington, D.C.:U.S. Patent and Trademark Office.
- Watkins M, Olivera BM, Hillyard DR, McIntosh JM, Jones RM (2004). .alpha.-conotoxin peptides. U.S. Patent No. 6,797,808. Washington, D.C.:U.S. Patent and Trademark Office.
- Walker CS, Shetty R, Jimenez EC, McIntosh JM, Olivera BM, Watkins M, Jones RM, Shen GS (2004). I-superfamily conotoxins. U.S. Patent No. 6,767,895. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM, Olivera BM, Cruz LJ, Corpuz GP, Jones RM, Garrett JE (2004). Conotoxin peptides. U.S. Patent No. 6,767,896. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM, et al (2004). Alpha-Conotoxin Peptides (Australia). U.S. Patent No. 770,076. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, McIntosh JM, Garrett JE, Cruz LJ, Jones RM, Cartier GE, Wagstaff JD (2004). Mu-conopeptides. U.S. Patent No. 6,727,226. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, Cartier GE, Watkins M, Hillyard DR, McIntosh JM, Layer RT, Jones RM (2004). O-superfamily conotoxin peptides. U.S. Patent No. 6,762,165. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM (2004). O-superfamily conotoxin peptides. U.S. Patent No. U.S. Patent 6,762,165. Washington, D.C.:U.S. Patent and Trademark Office.
- McCabe RT, Zhou L-M, Layer RT, Olivera BM, McIntosh JM (2002). Use of conantokins. U.S. Patent No. 6,399,574. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, McIntosh JM, McCabe RT, Layer RT, Zhou L-M (2001). Use of conantokins for treating pain. U.S. Patent No. 6,277,825. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, Layer RT, Watkins M, Hillyard DR, McIntosh JM, Schoenfeld R, Jones RM (2001). .alpha.-conotoxin peptides. U.S. Patent No. 6,268,473. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, McIntosh JM, Yoshikami D, Cartier GE, Luo S (2001). Uses of .alpha.-conotoxin peptides. U.S. Patent No. 6,265,541. Washington, D.C.:U.S. Patent and Trademark Office.
- McCabe RT, Zhou L-M, Layer RT, Olivera BM, McIntosh JM (2001). Use of conantokins. U.S. Patent No. 6,172,041. Washington, D.C.:U.S. Patent and Trademark Office.
- Shon K-J, Olivera BM, McIntosh JM (1999). Conotoxin peptides. U.S. Patent No. 5,990,295. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM, Kulak JM, Yoshikami D, Olivera BM (1999). Use of .alpha.-conotoxin MII to treat disorders resulting from nicotine-stimulated dopamine release. U.S. Patent No. 5,929,034. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM, Kulak JM, Yoshikami D, Olivera BM (1999). Use of .alpha.-conotoxin MII to treat disorders resulting from nicotine-stimulated dopamine release. U.S. Patent No. 5,922,679. Washington, D.C.:U.S. Patent and Trademark Office.
- Cruz LJ, Olivera BM, McIntosh JM, Jimenez E, Craig AG, Rivier JA, Julius D, England L (1999). Bromo-tryptophan conopeptides. U.S. Patent No. 5,889,147. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM, Cartier GE, Yoshikami D, Luo S, Olivera BM (1999). Conopeptides AuIA, AuIB and AuIC. U.S. Patent No. 5,866,682. Washington, D.C.:U.S. Patent and Trademark Office.
- McIntosh JM, Kulak JM, Yoshikami D, Olivera BM (1998). Use of .alpha.-conotoxin MII to treat disorders resulting from nicotine stimulated dopamine release. U.S. Patent No. 5,780,433. Washington, D.C.:U.S. Patent and Trademark Office.
- Shon K-J, Olivera BM, McIntosh JM, Hasson A, Spira ME (1998). Conotoxin peptides. U.S. Patent No. 5,719,264. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, Cruz LJ, Hillyard DR, McIntosh JM, Santos AO (1997). Conotoxin peptides. U.S. Patent No. 5,633,347. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, Cruz LJ, Hillyard DR, McIntosh JM, Santos AD (1997). Conotoxin peptides. U.S. Patent No. 5,595,972. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, Cruz LJ, Hillyard DR, McIntosh JM, Santos AD (1996). Process and primers for identifying nucleic acids encoding A-lineage conotoxin peptides. U.S. Patent No. 5,589,340. Washington, D.C.:U.S. Patent and Trademark Office.
- Olivera BM, Cruz LJ, Hillyard DR, McIntosh JM, Santos AD (1996). Conotoxin Peptides. U.S. Patent No. 5,514,774. Washington, D.C.:U.S. Patent and Trademark Office.