K.C. Brennan, M.D.

Locations

Schedule An Appointment	Clinical Office Address
(801) 585-7575	Imaging and Neurosciences Center Headache Clinic 729 Arapeen Way Salt Lake City, UT 84108 Map

Bio

K.C. Brennan, MD, recently joined the Department of Neurology as Assistant Professor, treating patients primarily in the Headache Clinic. In addition to his clinical responsibilities, Dr. Brennan is extensively involved in research examining the basic mechanisms of migraine.

Board Certification and Academic Information

Academic Departments	Neurology - Assistant Professor Neurobiology and Anatomy - Adjunct Assistant Professor
Academic Divisions	Headache and Neuro-Ophthalmology
Board Certification	American Board of Psychiatry & Neurology

Board Certification and Academic Information

Academic Departments	Neurology - Assistant Professor Neurobiology and Anatomy - Adjunct Assistant Professor
Academic Divisions	Headache and Neuro-Ophthalmology
Board Certification	American Board of Psychiatry & Neurology

Academic Office Locations

Academic Office Phone Number	Academic Office Address
(801) 581-8129	Brain Institute KC Brennan 383 Colorow Drive Salt Lake City, UT 84108

Academic Bio

Dr. K.C. Brennan is Assistant Professor of Neurology at the University of Utah School of Medicine. He was educated at Georgetown University and the Columbia College of Physicians and Surgeons. He was faculty at UCLA before being recruited to the University of Utah.

Dr. Brennan's clinical practice is dedicated to the headache disorders. These conditions, which include migraine, cluster headache, and post-traumatic headache, are disabling, often stigmatized, and poorly understood. It is becoming increasingly clear that these disorders are not 'just headache,' but complex disruptions of brain excitability and homeostasis.

Dr. Brennan spends much of his time examining the basic mechanisms of migraine. Cortical spreading depression (CSD), a massive spreading wave of brain activity, is a major interest. CSD is thought to be the basis of the migraine aura, and is likely a trigger for migraine pain. It is also involved in stroke, seizures, and traumatic brain injury. An understanding of CSD could thus lead to insights broadly relevant to neurological disease.

In addition to laboratory work, Dr. Brennan is involved in focused clinical research on the basic mechanisms of migraine.

Education History

Type	School	Degree
Other Training	Cold Spring Harbor Laboratory Summer Course Imaging Structure and Function in the Nervous System
Fellowship	David Geffen School of Medicine at UCLA, Department of Neurology Headache, Neurophysiology	Fellow
Residency	David Geffen School of Medicine at UCLA Neurology	Resident
Internship	George Washington University Medical Center Internal Medicine	Intern
Professional Medical	Columbia University College of Physicians and Surgeons Medicine	M.D.
Certification	Georgetown University Post-Baccalaureate Pre-Medical Sciences	Certificate
Undergraduate	Georgetown University School of Foreign Service	B.A.

Selected Provider Publications

Journal Article

1. Chang J, Brennan K, He D, Huang H, Miura R, Wilson P, Wylie (2013)A Mathematical Model of the Metabolic and Perfusion Effects on Cortical Spreding Depression  PLoS ONE,
2. Bogdanov VB, Bogdanov OV, Koulchitsky SV, Chauvel V, Multon S, Makarchuk MY, Brennan KC, Renshaw PF., Schoenen J(2013)Behavior in the open field predicts the number of KCl-induced cortical spreading depression in rats  Behavioural Brain Research, 23690 - 93
3. Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptacek LJ(2013)Casein kinase 1 delta mutations in familial migraine and advanced sleep phase  Science Translational Medicine, 1(5),1-11
4. Clarkson AN, Lopez-Valdes HE, Overmann JJ, Charles AC, Brennan KC, Thomas Carmichael S(2013)Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model  Journal of Cerebral Blood Flow and Metabolism, 33(5),716-723
5. Theriot JJ, Toga AW, Prakash N, Ju, YS, Brennan K(2012)Cortical sensory plasticity in a model of migraine with aura  Journal of Neuroscience, 32(44),15252-61
6. Ahn AH, Brennan K(2012)Unanswered questions in headache: how does a migraine attack stop?  Headache, 52(1),186-7
7. Tang YT, Kim J, Lopez-Valdes HE, Brennan KC, Ju Y(2011)Development and characterization of a microfluidic chamber incorporating fluid ports with active suction for localized chemical stimulation of brain slices.  Lab On a Chip, 11(13),2247-54
8. Chang JC, Brennan KC, Chou (2011)Tracking monotonically advancing boundaries in image sequences using graph cuts and recursive kernel shape priors  IEEE Transactions on Medical Imaging, PMC2215697
9. Chang JC, Brennan KC, Chou (2011)Tracking monotonically advancing boundaries in image sequences using graph cuts and recursuve kernel shape priors.  IEEE Transactions on Medical Imaging, 31(5),1008-20
10. Chang JC, Shook LL, Biag J, Nguyen EN, Toga AW, Charles AC, Brennan K(2010)Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression.  Brain, 133(Pt 4),996-1012
11. Lopez-Valdes HE, Beltran-Parrazal L, Brennan KC, Charles A(2010)Bradykinin increases resensitization of purinergic receptor signaling in glioma cells.  Cancer Cell International, 1035
12. Bates E, Nikai T, Brennan K, Fu YH, Charles A, Basbaum A, Ptacek L, Ahn (2009)Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice.  Cephalalgia,
13. Brennan KC, Beltran-Parrazal L, Lopez-Valdes HE, Theriot J, Toga AW, Charles A(2007)Distinct vascular conduction with cortical spreading depression.  Journal of Neurophysiology, 97(6),4143-51
14. Brennan KC, Romero Reyes M, Lopez Valdes HE, Arnold AP, Charles A(2007)Reduced threshold for cortical spreading depression in female mice.  Annals of Neurology, 61(6),603-6
15. Charles A, Flippen C, Romero Reyes M, Brennan K(2007)Memantine for prevention of migraine: a retrospective study of 60 cases.  Journal of Headache and Pain, The, 8(4),248-50
16. Beltran-Parrazal L, López-Valdés HE, Brennan KC, Díaz-Muñoz M, de Vellis J, Charles AC(2006)Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium.  American Journal of Physiology: Cell Physiology, 291(6),C1193-7
17. Brennan KC, Jurewicz EC, Ford B, Pullman SL, Louis E(2002)Is essential tremor predominantly a kinetic or a postural tremor? A clinical and electrophysiological study.  Movement Disorders, 17(2),313-6
18. Sakai N, Brennan K, Weiss L, Matile (1997)Toward Biomimetic Ion Channels Formed by Rigid-Rod Molecules: Length-Dependent Ion-Transport Activity of Oligo(p-Phenylene)s  Journal of the American Chemical Society, 1198726-8727

Review

1. Digre KB, Brennan K(2012)Shedding light on photophobia  Journal of Neuro-Ophthalmology,
2. Brennan KC, Charles (2010)An update on the blood vessel in migraine.  Current Opinion in Neurology, 23(3),266-74
3. Charles A, Brennan K(2010)The neurobiology of migraine.  Handbook of Clinical Neurology, 9799-108
4. Charles A, Brennan (2009)Cortical spreading depression-new insights and persistent questions.  Cephalalgia, 29(10),1115-24
5. Brennan KC, Charles (2009)Sleep and headache.  Seminars in Neurology, 29(4),406-18
6. Matsumoto J, Saver JL, Brennan KC, Ringman JM(2005)Mitochondrial encephalomyopathy with lactic acidosis and stroke (MELAS).  Reviews in Neurological Diseases, 2(1),30-4

Book Chapter

1. Charles A, Brennan K(2010)The neurobiology of migraine  , 9799-108
2. Brennan KC, Toga A(2009)Intraoperative optical imaging.  ,
3. CharlesAC, Brennan K(2008)Glial cell calcium signaling  ,
4. Brennan KC, Charles A(2008)Mechanisms of cortical spreading depression as targets for migraine therapy  ,

Conference Proceedings

1. Tang YT, Kim J, Lopez-Valdes H, Brennan KC, Ju Y(2010)Microfluidic Chamber with Active Suction Ports for Localized Chemical Stimulation of Brain Slices. Proceedings of IEEE 23rd International Conference on Micro Electro Mechanical Systems.  , 304-307

Editorial

1. Brennan KC, Ahn A(2013)Unanswered questions in headache: So what is photophobia, anyway?  , 53(10),1673-4
2. Brennan K(2011)Turn down the lights! An irritable occipital cortex in migraine without aura.  , 76(3),206-7
3. Charles A, Brennan K(2008)A touch of increased pain: cutaneous allodynia in migraine.  , 63(2),130-2
4. Charles A, Brennan K(2007)Sumatriptan-naproxen combination for acute migraine.  , 3(11),604-5

Abstract

1. Kaufmann D, Bates EA , Bahr S, White HS, and Brennan K(2012)Anti-migraine properties of Sec-butyl propylacetamide (SPD): a novel valproic acid amide analogue. Annual Snowbird Neuroscience Symposium. Salt Lake City, UT.  ,
2. Bogdanov VB, Misyura AG, Mammilov S, Multon S, Schoenen J, Brennan K(2012)Differential susceptibility and propagation of spreading depression by cortical depth. American Headache Society 54th Annual Meeting. Los Angeles, CA  ,
3. Chang JC, Chou T, He D, Huang H, Miura RM, Wilson PL, Wylie J and Brennan K(2012)Interconnected neural, vascular, and metabolic dysfunction during cortical spreading depression: a mathematical model. American Headache Society 54th Annual Scientific Meeting. Los Angeles, CA.  ,
4. Tanga YT, López-Valdésb HE, Kima J, Charlesb A, Ju YS, and Brennan K(2012)Minimum conditions for the induction of cortical spreading depression  ,
5. KC Brennan, M.D., Theriot J, Prakash N, Toga (2012)Potentiation and sharpening of sensory maps after spreading depression: a possible mechanism for altered sensorium in migraine.  ,
6. Brennan KC, Theriot J, Toga A, Prakash N, Ju Y(2011)Increased signal-to-noise in the sensory cortex after spreading depression: a possible mechanism for altered sensory perception in migraine. 15th Annual Congress of the International Headache Society, Berlin, Germany. Selected for Platform Presentation  ,
7. K.C. Brennan, Bogdanov V , Chang J , Multon S , Schultz N , Zyuzin J , van den Maagdenberg Arn, Charles A, Schoenen (2010)Anisotropy of cortical spreading depression: implications for migraine. 52nd Annual Meeting of the American Headache Society. Los Angeles, CA. Selected for Platform Presentation.  ,
8. Brennan KC, Chang J, Shook L, Biag J, Nguyen E, Toga AW, Charles AC(2009)Biphasic DC shift, hemoglobin desaturation, and neurovascular uncoupling in cortical spreading depression. 134th Annual Meeting of the American Neurological Association, Baltimore MD. Selected for Platform Presentation.  ,

Other

1. Brennan K, Digre K, Baggaley (2012)Headache- A Patient's Guide  ,

Clinical Trials

• Memantine for Enhanced Stroke Recovery
  Keywords: Stroke, Memantine, Motor Recovery, Rehabilitation
  Status: Active, not recruiting Principal Investigator: Alicia Bennett

The Scope Health Sciences Radio

• Chronic Migraines: A Tidal Wave of Activity in the Brain

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