Siwen Hu-Lieskovan,
PhD, MD
Languages Spoken: English
Dr. Siwen Hu-Lieskovan is an Associate Professor of Medicine, and Director of Solid Tumor Immunotherapy at the Huntsman Cancer Institute, University of Utah. She is a recent recruit from UCLA, where she received her Hematology/Oncology Fellowship training and held a faculty position under the mentorship of Dr. Antoni Ribas. She is a board-certified oncologist with clinical focus on melanoma and early phase testing of cancer immunotherapies in solid tumors. She is experienced with protocol development and conduct of immunotherapy-based clinical trials, and has been a principal investigator of industry-, investigator- and cooperative group-initiated clinical trials testing immune checkpoint inhibitors, oncolytic viruses, cancer vaccines and other immune-modulatory agents, as well as cell therapy with genetically modified T cells and hematopoietic stem cells. Dr. Hu-Lieskovan chairs the SWOG Immunotherapeutics Committee, and is a study chair and translational lead of several cross-NCTN protocols initiated by SWOG, including the immunoMATCH trial. She is also a consultant on cancer immunotherapy drug development strategies for the pharmaceutical and biotechnology industry.
Dr. Hu-Lieskovan is a physician scientist with research focus on characterization of tumor immune microenvironment, development of biomarkers to predict response and resistance to immunotherapies, and combination strategies to overcome immune resistance, by studying patient-derived clinical samples and immune-competent (syngeneic) animal models. In the past, she and her research teams made contributions in understanding the role of driver mutations in oncogenesis and immune evasion, mechanisms of response and resistance to immune checkpoint inhibitors, and developing novel drug delivery systems. She led the first studies showing efficacy of nanoparticle delivered siRNA targeting oncogenes in treating metastatic cancers, and synergistic effect of combining BRAF and MEK inhibitors with immunotherapy in BRAF mutant melanoma. She has authored/co-authored research articles, reviews, editorials and book chapters in peer-reviewed journals including Nature, Science Translational Medicine, Cell, New England Journal of Medicine, etc. She is a recipient of the prestigious National Cancer Institute (NCI) Cancer Clinical Investigator Team Leadership Award (CCITLA), American Society of Clinical Oncologist (ASCO) Young Investigator Award (YIA) and Career Development Award, the American Association for Cancer Research (AACR) Sharp Award, the Hope Foundation Dr. Coltman Award, the Melanoma Research Alliance YIA and Team Science Award, the Tower Research Foundation Award, the UCLA KL2 Translational Award, the Daniel Von Hoff Innovative Protocol Award, among others. Siwen is a member of the NCI Investigational Drug Steering Committee (IDSC) Immunotherapy Task Force, Society of ImmunoTherapy of Cancer (SITC) Biomarker Taskforce, ASCO, and AACR. She was an associate director of the UCLA Parker Institute of Cancer Immunotherapy supervising biobanking and translational studies. She currently serves as co-Chair of the SITC Biomarker Taskforce Resources and Useful Tool Subcommittee, and Leader of the ASCO annual meeting Education Committee Developmental Therapeutics Immunotherapy Track.
Clinical Locations
Clinic 2C, Dermatology/Melanoma
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Associate Professor |
| Academic Divisions | Oncology |
| Board Certification | American Board of Internal Medicine (Sub: Medical Oncology) |
Patient Rating
The Patient Rating score is an average of all responses to care provider related questions on our nationally-recognized Press Ganey Patient Satisfaction Survey.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
Likelihood of recommending care provider
4.9/ 5
Care provider's explanation of condition/problem
4.9/ 5
Care provider's effort to include me in decisions
4.9/ 5
Wait time at clinic
4.6/ 5
Care provider's concern for questions & worries
4.9/ 5
Patient Comments
Patient comments are gathered from our Press Ganey Patient Satisfaction Survery and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
UofU Patient
September 22, 2022
HUNTSMAN CANCER CENTER
I feel very confident in Dr. Hu, her knowledge, understanding of my health needs and her care, as well as that of my whole team at Huntsman.
UofU Patient
August 05, 2022
HUNTSMAN CANCER CENTER
Dr. Hu was so helpful in explaining my condition, treatment options and possible side effects, etc. It was a lot of information, and she had answers for each question / concern and I have total confidence in her ability to provide the best care and treatment options available. I am so grateful to have her for my care provider and appreciate her very much.
UofU Patient
June 11, 2022
HUNTSMAN CANCER CENTER
Dr. Hu has is a very caring, knowledgeable, compassionate and empathetic professional that has been displayed in all of my visits. She is great and has been very comforting for me and my family.
UofU Patient
May 23, 2022
HUNTSMAN CANCER CENTER
The Dr spoke directly to me the patient. Asked what I knew about my cancer and then addressed concerns and explained what I could decide to do or not do. Ultimately it was my decision.
UofU Patient
April 17, 2022
HUNTSMAN CANCER CENTER
The Doctor spent a significant amount of time explaining my condition, my choices, how the treatment works and potential risks.
UofU Patient
February 21, 2022
HUNTSMAN CANCER CENTER
Dr Hu is the very best.
UofU Patient
January 28, 2022
HUNTSMAN CANCER CENTER
Your reputation proceeds you!!!
UofU Patient
January 03, 2022
HUNTSMAN CANCER CENTER
I have an extremely capable team, always looking out for me
UofU Patient
December 28, 2021
HUNTSMAN CANCER CENTER
Very good and helpful
UofU Patient
December 28, 2021
HUNTSMAN CANCER CENTER
For this visit most of these questions were irrelevant. We're waiting for the scans that will be done in January to see the trajectory of the disease and the doctor did not discuss what the treatment option choices might be based on what is seen on the upcoming scans. I think I would have preferred for the doctor to speculate a bit about the future but I was OK with waiting.
UofU Patient
December 17, 2021
HUNTSMAN CANCER CENTER
She is an awesome doctor. Very thorough, checked my understanding, very knowledgeable. Glad I have her on my care team.
UofU Patient
November 13, 2021
HUNTSMAN CANCER CENTER
Dr. Hu-Lieskovan is awesome! She took the necessary time needed to thoroughly explain my diagnosis and answered all of our questions regarding treatment. We didn't feel like we were being rushed in and out of the office.
UofU Patient
October 08, 2021
HUNTSMAN CANCER CENTER
The doctor was absolutely fantastic! I feel so good bout her directing my immunotherapy treatments!
UofU Patient
October 01, 2021
HUNTSMAN CANCER CENTER
First time seeing Dr. Hu-Lieskovan & she exceeded my expectations! She was so engaged with my care & really listened to & answered all my questions. My confidence in my medical needs being met soared. I am honored & happy to be under her care. Dr. Hu-Lieskovan's expertise allows me to have quality of life as I travel thru this Melanoma journey. 5++++++ rating!
UofU Patient
June 20, 2021
HUNTSMAN CANCER CENTER
I appreciated that she took so much time discussing the scan results with us and explaining what they might mean. It was unexpected and disappointing "bad news" and I think she handled it very well - she was helping us to be prepared to choose among the treatment options if biopsy confirms a recurrence of malignancy.
UofU Patient
May 12, 2021
HUNTSMAN CANCER CENTER
again very through
UofU Patient
May 01, 2021
HUNTSMAN CANCER CENTER
I was very glad we made the effort to drive to SLC for the appointment.
UofU Patient
February 05, 2021
HUNTSMAN CANCER CENTER
Dr Hu has been fantastic, shows concern, is knowledgeable and empathetic - she is the best
UofU Patient
December 12, 2020
HUNTSMAN CANCER CENTER
Dr. Hu was fantastic.
Dr. Siwen Hu-Lieskovan is an Associate Professor of Medicine, and Director of Solid Tumor Immunotherapy at the Huntsman Cancer Institute, University of Utah. She is a recent recruit from UCLA, where she received her Hematology/Oncology Fellowship training and held a faculty position under the mentorship of Dr. Antoni Ribas. She is a board-certified oncologist with clinical focus on melanoma and early phase testing of cancer immunotherapies in solid tumors. She is experienced with protocol development and conduct of immunotherapy-based clinical trials, and has been a principal investigator of industry-, investigator- and cooperative group-initiated clinical trials testing immune checkpoint inhibitors, oncolytic viruses, cancer vaccines and other immune-modulatory agents, as well as cell therapy with genetically modified T cells and hematopoietic stem cells. Dr. Hu-Lieskovan chairs the SWOG Immunotherapeutics Committee, and is a study chair and translational lead of several cross-NCTN protocols initiated by SWOG, including the immunoMATCH trial. She is also a consultant on cancer immunotherapy drug development strategies for the pharmaceutical and biotechnology industry.
Dr. Hu-Lieskovan is a physician scientist with research focus on characterization of tumor immune microenvironment, development of biomarkers to predict response and resistance to immunotherapies, and combination strategies to overcome immune resistance, by studying patient-derived clinical samples and immune-competent (syngeneic) animal models. In the past, she and her research teams made contributions in understanding the role of driver mutations in oncogenesis and immune evasion, mechanisms of response and resistance to immune checkpoint inhibitors, and developing novel drug delivery systems. She led the first studies showing efficacy of nanoparticle delivered siRNA targeting oncogenes in treating metastatic cancers, and synergistic effect of combining BRAF and MEK inhibitors with immunotherapy in BRAF mutant melanoma. She has authored/co-authored research articles, reviews, editorials and book chapters in peer-reviewed journals including Nature, Science Translational Medicine, Cell, New England Journal of Medicine, etc. She is a recipient of the prestigious National Cancer Institute (NCI) Cancer Clinical Investigator Team Leadership Award (CCITLA), American Society of Clinical Oncologist (ASCO) Young Investigator Award (YIA) and Career Development Award, the American Association for Cancer Research (AACR) Sharp Award, the Hope Foundation Dr. Coltman Award, the Melanoma Research Alliance YIA and Team Science Award, the Tower Research Foundation Award, the UCLA KL2 Translational Award, the Daniel Von Hoff Innovative Protocol Award, among others. Siwen is a member of the NCI Investigational Drug Steering Committee (IDSC) Immunotherapy Task Force, Society of ImmunoTherapy of Cancer (SITC) Biomarker Taskforce, ASCO, and AACR. She was an associate director of the UCLA Parker Institute of Cancer Immunotherapy supervising biobanking and translational studies. She currently serves as co-Chair of the SITC Biomarker Taskforce Resources and Useful Tool Subcommittee, and Leader of the ASCO annual meeting Education Committee Developmental Therapeutics Immunotherapy Track.
Academic Locations
Research Statement
Dr. Hu-Lieskovan’s laboratory uses cutting-edge technologies to investigate mechanisms of resistance to immunotherapy, develop novel combination strategies to overcome resistance, improve efficacy, as well as monitor and prevent immunotherapy-induced toxicities. Her team also conducts clinical trials to bring the discovery from her laboratory to the clinic, to improve the effectiveness and tolerability of immunotherapy, with the ultimate goal of bringing the survival benefit of immunotherapy to every patient.
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Associate Professor |
| Academic Divisions | Oncology |
| Board Certification | American Board of Internal Medicine (Sub: Medical Oncology) |
Education History
| Fellowship | David Geffen School of Medicine, University of California Los Angeles Hematology/Oncology Clinical Fellow, 2014 |
| Internship/Residency | University of Southern California Internal Medicine Intern/Resident, 2011 |
| Postdoctoral Fellowship | Children’s Hospital Los Angeles Pathology Postdoctoral Fellow, 2008 |
| Doctoral Training | Keck School of Medicine, University of Southern California Pathobiology Ph.D., 2004 |
| Professional Medical | China Medical University Medicine M.D., 1998 |
Selected Publications - Journal Articles
Journal Article
- Diab A, Hamid O, Thompson JA, Ros W, Eskens FALM, Doi T, Hu-Lieskovan S, Klempner SJ, Ganguly B, Fleener C, Wang X, Joh T, Liao K, Salek-Ardakani S, Taylor CT, Chou J, El-Khoueiry AB (2021). A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients with Locally Advanced or Metastatic Cancers. Clin Cancer Res, 28(1), 71-83.
- Wang X, Haaland B, Hu-Lieskovan S, Colman H, Holmen SL (2021). First line immunotherapy extends brain metastasis free survival, improves overall survival, and reduces the incidence of brain metastasis in patients with advanced melanoma. Cancer Rep (Hoboken), 4(6), e1419.
- Hu-Lieskovan S, Braiteh F, Grilley-Olson JE, Wang X, Forgie A, Bonato V, Jacobs IA, Chou J, Johnson ML (2021). Association of Tumor Mutational Burden and Immune Gene Expression with Response to PD-1 Blockade by Sasanlimab Across Tumor Types and Routes of Administration. Target Oncol, 16(6), 773-787.
- Diab A, Hamid O, Thompson J, Ros W, Eskens F, Doi T, Hu-Lieskovan S, Klempner S, Ganguly B, Fleener C, Wang X, Jo T, Liao K, Salek-Ardakani S, Taylor C, Chou J, El-Khoueiry A (2021). A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients With Locally Advanced or Metastatic Cancers. Clin Cancer Res.
- Pokorny R, McPherson JP, Haaland B, Grossmann KF, Luckett C, Voorhies BN, Sageser DS, Wallentine J, Tolman Z, Hu-Lieskovan S, Swami U (2021). Real-world experience with elective discontinuation of PD-1 inhibitors at 1 year in patients with metastatic melanoma. J Immunother Cancer.
- Hu-Lieskovan S, Bhaumik S, Dhodapkar K, Grivel JJB, Gupta S, Hanks BA, Janetzki S, Kleen TO, Koguchi Y, Lund AW, Maccalli C, Mahnke YD, Novosiadly RD, Selvan SR, Sims T, Zhao Y, Maecker HT (2020). SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery. J Immunother Cancer, 8(2).
- Poran A, Scherer J, Bushway ME, Besada R, Balogh KN, Wanamaker A, Williams RG, Prabhakara J, Ott PA, Hu-Lieskovan S, Khondker ZS, Gaynor RB, Rooney MS, Srinivasan L (2020). Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1. Cell Rep Med, 1(8), 100141.
- Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L (2020). A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer. Cell, 183(2), 347-362.e24.
- Grossman D, Okwundu N, Bartlett EK, Marchetti MA, Othus M, Coit DG, Hartman RI, Leachman SA, Berry EG, Korde L, Lee SJ, Bar-Eli M, Berwick M, Bowles T, Buchbinder EI, Burton EM, Chu EY, Curiel-Lewandrowski C, Curtis JA, Daud A, Deacon DC, Ferris LK, Gershenwald JE, Grossmann KF, Hu-Lieskovan S, Hyngstrom J, Jeter JM, Judson-Torres RL, Kendra KL, Kim CC, Kirkwood JM, Lawson DH, Leming PD, Long GV, Marghoob AA, Mehnert JM, Ming ME, Nelson KC, Polsky D, Scolyer RA, Smith EA, Sondak VK, Stark MS, Stein JA, Thompson JA, Thompson JF, Venna SS, Wei ML, Swetter SM (2020). Prognostic Gene Expression Profiling in Cutaneous Melanoma: Identifying the Knowledge Gaps and Assessing the Clinical Benefit. JAMA Dermatol, 156(9), 1004-1011.
- Torrejon DY, Abril-Rodriguez G, Champhekar AS, Tsoi J, Campbell KM, Kalbasi A, Parisi G, Zaretsky JM, Garcia-Diaz A, Puig-Saus C, Cheung-Lau G, Wohlwender T, Krystofinski P, Vega-Crespo A, Lee CM, Mascaro P, Grasso CS, Berent-Maoz B, Comin-Anduix B, Hu-Lieskovan S, Ribas A (2020). Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade. Cancer Discov, 10(8), 1140-1157.
- Abril-Rodriguez G, Torrejon DY, Liu W, Zaretsky JM, Nowicki TS, Tsoi J, Puig-Saus C, Baselga-Carretero I, Medina E, Quist MJ, Garcia AJ, Senapedis W, Baloglu E, Kalbasi A, Cheung-Lau G, Berent-Maoz B, Comin-Anduix B, Hu-Lieskovan S, Wang CY, Grasso CS, Ribas A (2022). Publisher Correction: PAK4 inhibition improves PD-1 blockade immunotherapy. Nat Cancer, 1(2), 264.
- Parisi G, Saco J, Salazar F, Tsoi J, Krystofinski P, Puig Saus C, Zhang R, Zhou J, Cheung-Lau G, Garcia AJ, Grasso CS, Tavar R, Hu-Lieskovan S, Mackay S, Zalevsky J, Bernatchez C, Diab A, Wu A, Comin-Anduix B, Charych DH, Ribas A (Jan 2020). Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist. Nat Commun, 11(1), 660.
- Abril-Rodriguez G, Torrejon DY, Liu W, Zaretsky JM, Nowicki TS, Tsoi J, Puig-Saus C, Baselga-Carretero I, Medina E, Quist MJ, Garcia AJ, Senapedis W, Baloglu E, Kalbasi A, Cheung-Lau G, Berent-Maoz B, Comin-Anduix B, Hu-Lieskovan S, Wang CY, Grasso CS, Ribas A (2019). PAK4 inhibition improves PD-1 blockade immunotherapy. Nat Cancer, 1(1), 46-58.
- Abril-Rodriguez G, Torrejon T, Zaretsky J, Nowicki T, Tsoi J, Baselga Carretero I, Medina E, Quist M, Senapedis W, Baloglu E, Cheung-Lau G, Puig-Saus C, Berent-Maoz B, Comin-Anduix B, Hu-Lieskovan S, Grasso C, Ribas A (Jan 2020). PAK4 inhibition reverses T cell exclusion in cancer and improves PD-1 blockade immunotherapy. 1, 46-58.
- Moser JC, Chen D, Hu-Lieskovan S, Grossmann KF, Patel S, Colonna SV, Ying J, Hyngstrom JR (Nov 2019). Real-world survival of patients with advanced BRAF V600 mutated melanoma treated with front-line BRAF/MEK inhibitors, anti-PD-1 antibodies, or nivolumab/ipilimumab. Cancer Med.
- Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L (Oct 2019). Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell, 25(4), 542-557.e9.
- Johnson ML, Braiteh F, Grilley-Olson JE, Chou J, Davda J, Forgie A, Li R, Jacobs I, Kazazi F, Hu-Lieskovan S (May 2019). Assessment of Subcutaneous vs Intravenous Administration of Anti-PD-1 Antibody PF-06801591 in Patients With Advanced Solid Tumors: A Phase 1 Dose-Escalation Trial. JAMA Oncol.
- Hu-Lieskovan S, Lisberg A, Zaretsky J, Wells D, Han M, Shintaku I, Wolf B, Abarca P, Slamon D, Goldman JW, Dubinett S, Ribas A, Garon EB (May 2019). Tumor characteristics associated with benefit from pembrolizumab in advanced non-small cell lung cancer. Clin Cancer Res.
- Allen CT, Lee S, Norberg SM, Kovalovsky D, Ye H, Clavijo PE, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley JL, Trepel J, Hinrichs CS (May 2019). Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis. 7(1), 119.
- Nowicki T, Berent-Maoz B, Cheung-Lau G, Huang RR, Wang X, Tsoi J, Kaplan-Lefko P, Cabrera P, Tran J, Pang J, Macabali M, Garcilazo IP, Carretero IB, Kalbasi A, Cochran A, Grasso C, Hu-Lieskovan S, Chmielowski B, Comin-Anduix B, Singh A, Ribas A (Apr 2019). A Pilot Trial of the Combination of Transgenic NY-ESO-1-reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination With or Without Ipilimumab. Clin Cancer Res, 25(7), 2096-2108.
- Bethune MT, Li XH, Yu J, McLaughlin J, Cheng D, Mathis C, Moreno BH, Woods K, Knights AJ, Garcia-Diaz A, Wong S, Hu-Lieskovan S, Puig-Saus C, Cebon J, Ribas A, Yang L, Witte ON, Baltimore D (Oct 2018). Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Proc Natl Acad Sci U S A.
- Kugel CH 3rd, Douglass SM, Webster MR, Kaur A, Liu Q, Yin X, Weiss SA, Darvishian F, Al-Rohil RN, Ndoye A, Behera R, Alicea GM, Ecker BL, Fane M, Allegrezza MJ, Svoronos N, Kumar V, Wang DY, Somasundaram R, Hu-Lieskovan S, Ozgun A, Herlyn M, Conejo-Garcia JR, Gabrilovich D, Stone EL, Nowicki TS, Sosman J, Rai R, Carlino MS, Long GV, Marais R, Ribas A, Eroglu Z, Davies MA, Schilling B, Schadendorf D, Xu W, Amaravadi RK, Menzies AM, McQuade JL, Johnson DB, Osman I, Weeraratna AT (Jun 2018). Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations. . Clin Cancer Res.
- Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJ, Quist M, Nowak JA, Nishihara R, Qian ZR, Inamura K, Morikawa T, Nosho K, Abril-Rodriguez G, Connolly C, Escuin-Ordinas H, Geybels MS, Grady WM, Hsu L, Hu-Lieskovan S, Huyghe JR, Kim YJ, Krystofinski PE, Leiserson MD, Montoya DJ, Nadel BB, Pellegrini M, Pritchard CC, Puig-Saus C, Quist EH, Raphael BJ, Salipante SJ, Shin DS, Shinbrot E, Shirts B, Shukla S, Stanford JL, Sun W, Tsoi J, Upfill-Brown A, Wheeler DA, Wu CJ, Yu M, Zaidi SH, Zaretsky JM, Gabriel SB, Lander ES, Garraway LA, Hudson TJ, Fuchs CS, Ribas A, Ogino S, Peters U (Mar 2018). Genetic mechanisms of immune evasion in colorectal cancer. Cancer Discov.
- Eroglu Z Zaretsky J Hu-Lieskovan S Kim DW, Algazi A, Johnson D, Liniker E, Kong B, Munhoz R, Rapisuwon S, Chmielowski B, Homet Moreno B, Cherry G, Berent-Maoz B, Comin-Anduix B, Wang X, Tumeh PC, Shintaku IP, Hugo W, Lo RS, Sosman JA, Joseph R, Postow M, Hwu W-J, Messina J, Long G, Ribas A Equal contribution as first authors, Corresponding authors (Jan 2018). High response to PD-1 blockadein desmoplastic melanoma. Nature, 553(7688), 347-350.
- Tolcher A, Sznol M, Hu-Lieskovan S, Papadopoulos KP, Patnaik A, Rasco DW, Di Gravio D, Huang B, Gambhire D, Chen Y, Thall AD, Pathan N, Schmidt EV, Chow LQ (Jun 2017). Phase Ib study of utomilumab (PF-05082566), a 4-1BB/CD137 agonist, in combination with pembrolizumab in patients with advanced solid tumors. Clin Cancer Res.
- Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang X, Parisi G, Saus CP, Torrejon DY, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Damoiseaux R, Lo RS, Ribas A (2017). Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell Rep, 19(6), 1189-1201.
- Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, Palaskas N, Abril Rodriguez G, Parisi G, Azhdam A, Chmielowski B, Cherry G, Seja E, Berent-Maoz B, Shintaku IP, Le DT, Pardoll DM, Diaz LA, Tumeh PC, Graeber TG, Lo RS, Comin-Anduix B, Ribas A (Nov 2016). Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations. Cancer Discov.
- Homet Moreno B, Zaretsky JM, Garcia-Diaz A, Tsoi J, Parisi G, Robert L, Meeth K, Ndoye A, Bosenberg M, Weeraratna AT, Graeber TG, Comin-Anduix B, Hu-Lieskovan S Ribas A Corresponding Authors (Oct 2016). Response to programmed cell death-1 blockade in a murine melanoma syngeneic model requires costimulation, CD4, and CD8 T cells. Cancer Immunol Res, 4(10), 845-857.
- Zaretsky JM, Garcia Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Rodriguez GA, Sandoval S, Barthly L, Saco J, Homet Moreno B, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez P, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher T, Lo RS, Ribas A (Sep 2016). Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma. N Engl J Med, 375(9), 819-29.
- Hugo W, Zaretsky JM, Sun L, Song C, Moreno BH, Hu-Lieskovan S, Berent-Maoz B, Pang J, Chmielowski B, Cherry G, Seja E, Lomeli S, Kong X, Kelley MC, Sosman JA, Johnson DB, Ribas A, Lo RS (Mar 2016). Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma. Cell, 165(1), 35-44.
- Homet Moreno B, Mok S, Robert L, Comin-Anduix B, Hu-Lieskovan S, Ribas A (Aug 2015). Combined Treatment with Dabrafenib and Trametinib with Immune-stimulating Antibodies for BRAF Mutant Melanoma. Oncoimmunology, 5(7), e1052212.
- Mok S, Tsoi J, Koya RC, Hu-Lieskovan S, West BL, Bollag G, Graeber TG, Ribas A (May 2015). Inhibition of CSF-1R Improves Antitumor Efficacy of BRAF Inhibition. BMC Cancer, 15(1), 356.
- Hu-Lieskovan S, Mok S, Homet Moreno B, Tsoi J, Robert L, Goedert L, Koya KC, Graeber T, Comin-Anduix B, Ribas A (Mar 2015). Improved Antitumor Activity of Immunotherapy with BRAF and MEK inhibitors in BRAFV600E mutant melanoma. Sci Transl Med, 7(279), 279.
- Hu-Lieskovan S, Vallbohmer D, Zhang W, Yang D, Pohl A, Labonte MJ, Grimminger PP, Hlscher AH, Semrau R, Arnold D, Dellas K, Debucquoy A, Haustermans K, Machiels JP, Sempoux C, Rdel C, Bracko M, Velenik V, Lenz HJ (Aug 2011). EGF61 polymorphism predicts complete pathologic response to cetuximab-based chemoradiation independent of KRAS status in locally advanced rectal cancer patients. . Clin Cancer Res, 17(15), 5161-9.
- Zhang W, Winder T, Ning Y, Pohl A, Yang D, Kahn M, Lurje G, Labonte MJ, Wilson PM, Gordon MA, Hu-Lieskovan S, Mauro DJ, Langer C, Rowinsky EK, Lenz HJ (Jan 2011). A let-7 microRNA-binding site polymorphism in 3'-untranslated region of KRAS gene predicts response in wild-type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy. Ann Oncol, 22(1), 104-9.
- Zwerner P, Joo J, Warner KL, Christensen L, Hu-Lieskovan S, Triche TJ, May WA (May 2008). The EWS/FLI1 oncogenic transcription factor deregulates GLI1. Oncogene, 27(23), 3282-91.
- Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ (Oct 2005). Sequence-specific knockdown of EWS-FLI1 by targeted, non-viral delivery of siRNA inhibits tumor growth in a murine model of metastatic Ewing’s sarcoma. Cancer Res, 65(19), 8984-8992.
- Popielarski SR, Hu-Lieskovan S, French SW, Triche TJ, Davis ME (Aug 2005). A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 2. In vitro and in vivo uptake results. Bioconjug Chem, 16(5), 1071-80.
- Hu-Lieskovan S, Zhang J, Schofield DE, Shimada H, Wu L, Triche TJ (Jun 2005). EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing’s family of tumors. Cancer Res, 65(11), 4633-44.
- Heidel JD, Hu S, Liu XF, Triche TJ, Davis ME (Dec 2004). Lack of interferon response in animals to naked siRNAs. Nat Biotechnol, 22(12), 1579-82.
- Zhang J, Hu S, Schofield D, Sorensen P, Triche TJ (Sep 2004). Selective usage of D type cyclins by Ewing's tumors and rhabdomyosarcomas. Oncogene, 64(17), 6026-34.
- Hamid O, Chiappori AA, Thompson JA, Doi T, Hu-Lieskovan S, Eskens FA, Ros W, Diab A, Spano J-P, Rizvi NA, Wasser JS, Angevin E, Ott PA, Forgie A, Yang W, Liao KK, Bonato V, Chou J, El-Khoueiry AB (). First-in-human study of an OX40 (ivuxolimab) and 4-1BB/CD137 (utomilumab) agonistic antibody combination in patients with advanced solid tumors. (Epub ahead of print)
Review
- Sankar K, Ye JC, Li Z, Zheng L, Song W, Hu-Lieskovan S (2022). The role of biomarkers in personalized immunotherapy. [Review]. Biomark Res, 10(1), 32.
- Yuan J, Khilnani A, Brody J, Andtbacka RHI, Hu-Lieskovan S, Luke JJ, Diab A, Marabelle A, Snyder A, Cao ZA, Hodi FS (2021). Current strategies for intratumoural immunotherapy - Beyond immune checkpoint inhibition. [Review]. Eur J Cancer, 157, 493-510.
- Okwundu N, Grossman D, Hu-Lieskovan S, Grossmann KF, Swami U (2020). The dark side of immunotherapy. [Review]. Ann Transl Med, 9(12), 1041.
- Hu-Lieskovan S, Malouf GG, Jacobs I, Chou J, Liu L, Johnson ML (2021). Addressing resistance to immune checkpoint inhibitor therapy: an urgent unmet need. [Review]. Future Oncol, 17(11), 1401-1439.
- Moser J, Hu-Lieskovan S (Apr 2020). Mechanisms of Resistance to PD-1 Checkpoint Blockade. [Review]. Drugs, 80(5), 459-465.
- Davda J, Declerck P, Hu-Lieskovan S, Hickling T, Jacobs I, Chou J, Salek-Ardakani S, Kraynov E (April 2019). Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics. [Review]. J Immunother Cancer, 7, Article: 105.
- Nowicki T, Hu-Lieskovan S, Ribas A (Jan/Feb 2018). Mechanisms of Resistance to PD-1 and PD-L1 blockade. [Review]. Cancer J, 24(1), 47-53.
- Sharma P, Hu-Lieskovan S, Wargo J, Ribas A (February 2017). Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy. [Review]. Cell, 168(4), 707-723.
- Hu-Lieskovan S, Ribas R (Jan/Feb 2017). New combination strategies using PD-1/ L1 checkpoint inhibitors as a backbone. [Review]. Cancer J, 23(1), 10-22.
- Ribas A, Hu-Lieskovan S (November 2016). What does PD-L1 positive or negative tumors mean? Perspective for Clinical Correlates of Immunotherapy. [Review]. J Exp Med, 213(13), 2835-2840.
- Robert L, Ribas A, Hu-Lieskovan S (February 2016). Combining targeted therapy with immunotherapy. Can 1 + 1 equal more than 2? [Review]. Semin Immunol, 28(1), 73-80.
- Hu-Lieskovan S, Robert L, Homet Moreno B, Ribas A (July 2014). Combining targeted therapy with immunotherapy in BRAF mutant melanoma: promise and challenges. [Review]. J Clin Oncol, 32(21), 2248-2254.
- Sankar K, Ye J, Li Z, Zheng L, Song W, Hu-Lieskovan S (). The role of biomarkers in personalized immunotherapy. [Review]. Biomark Res.
Book Chapter
- McKean W, Moser J, Rimm D, Hu-Lieskovan S (2020). Biomarkers in Precision Cancer Immunotherapy: Promise and Challenges. In ASCO Educational Book 40 (2020) (pp. e275-e291).
- Fares CM, Van Allen EM, Drake CG, Allison JP, Hu-Lieskovan S (Jan 2019). Mechanisms of Resistance to Immune Checkpoint Blockade: Why Doesn't Checkpoint Inhibitor Immunotherapy Work for All Patients? In ASCO Educational Book 39 (2019) (pp. 147-164).
- Hu-Lieskovan S, Chmielowski B, Ribas A (2017). Cancer Immunotherapy. In Chmielowski B, Territo MC (Eds.), Manual of Clinical Oncology (Eighth Edition). Lippincott Williams & Wilkins.
- Sharma S, Hu-Lieskovan S, Dubinett SM, Moon Lee J (2015). Addressing inflammation with immunotherapy. In Dubinett S (Ed.), Inflammation and Lung Cancer (Second Edition). New York: Springer.
Commentary
- McKean W, Hu-Lieskovan S (2021). Combination Immunotherapy With IDO Inhibitors: Defining a Future Through Biomarker-Guided Patient Selection. .
Editorial
- Pal S, Hu-Lieskovan S, Agarwal N (Sep 2019). Can pegylated IL-10 add to a backbone of PD-1 inhibition for solid tumours? 20(11), 1473-1474.
- Hu-Lieskovan S, Homet Moreno B, Ribas A (June 2018). Excluding T cells: Is β-catenin the full story? 27(6), 749-750.
Letter
Video/Film/CD/Web/Podcast
- Hu-Lieskovan S, Ribas A (2013). ASCO 2013 Highlights: Melanoma (review) [Web]. Available: Oncofacts.com.
Global Impact
Education History
| Professional Medical | China Medical University Medicine M.D. |