J. Michael McIntosh
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J. Michael McIntosh, MD

Languages spoken: English

Clinical Locations

Primary Location

University of Utah Hospital

Psychiatry
50 N Medical Dr
Salt Lake City , UT 84132
801-581-7951
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J. Michael McIntosh, MD, graduated from the University of California at Los Angeles Medical School, completed residency training at the University of Colorado and is board-certified in general adult psychiatry. He is Professor with tenure in the Department of Psychiatry and Research Professor in the Department of Biology. Dr. McIntosh is also the Medical Director of the SLVAMC Behavioral Health Clinic where he sees medically complex patients with co-morbid psychiatric conditions. He is ranked by US News and World Reports among the top 1% of doctors in the United States.

Specialties

Board Certification

American Board of Psychiatry & Neurology (Psychiatry)

J. Michael McIntosh, MD, graduated from the University of California at Los Angeles Medical School, completed residency training at the University of Colorado and is board-certified in general adult psychiatry. He is Professor with tenure in the Department of Psychiatry and Research Professor in the Department of Biology. Dr. McIntosh is also the Medical Director of the SLVAMC Behavioral Health Clinic where he sees medically complex patients with co-morbid psychiatric conditions. He is ranked by US News and World Reports among the top 1% of doctors in the United States.

Board Certification and Academic Information

Academic Departments Psychiatry -Professor
Academic Divisions Adult Psychiatry
Board Certification
American Board of Psychiatry & Neurology (Psychiatry)

Education history

Undergraduate Biology - University of Utah B.S.
Professional Medical Medicine - University of California - Los Angeles M.D.
Internship Psychiatry - University of Colorado at Denver and Health Sciences Center Intern
Residency Psychiatry - University of Colorado at Denver and Health Sciences Center Resident
Residency Psychiatry - University of Utah School of Medicine Resident

Selected Publications

Journal Article

  1. Bhattacharjee B, Noviello CM, Rahman MM, Mayer JP, Gajewiak J, McIntosh JM, Hibbs RE, Stowell MH (2025). Shape-shifting conotoxins reveal divergent pore-targeting mechanisms in nicotinic receptors. Structure (London, England,
  2. Khilji MS, Hackney CM, Koch TL, Hone AJ, Rogalski A, Watkins M, Tun J, McIntosh JM, Olivera B, Safavi-Hemami H, Teilum K, Ellgaard (2025). Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. Protein science, 34(11), e70333.
  3. Wolf PMK, Hanke D, Singh VK, Keller HL, Ettischer LJ, Teppe L, Amati AL, Hecker A, Husain-Syed F, Rohde M, Nuber UA, Büttner K, McIntosh JM, Liese J, Mazurek S, Grau V, Richter (2025). The ATP-mediated cytokine release by macrophages is down-modulated by unconventional ¿9* nicotinic acetylcholine receptors. Frontiers in immunology, 16, 1661114.
  4. Andleeb H, Papke RL, Richter K, Grau V, Hone AJ, Kerr A, McIntosh JM, Stokes C, Thakur G (2025). Stereoisomers of Chiral Methyl-Substituted Symmetric and Asymmetric Aryl Piperazinium Compounds Exhibit Distinct Selectivity for ¿9 and ¿7 Nicotinic Acetylcholine Receptors. ACS chemical neuroscience, 16(14), 2665-2681.
  5. Giglio ML, Flórez-Salcedo P, Azam L, Watkins M, Koch TL, Basgall-De la Rosa E, Douglass AD, McIntosh JM, Olivera BM, Gajewiak (2025). An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon ¿-Conotoxins Targeting Muscle nAChRs. FASEB journal, 39(12), e70698.
  6. Guo M, Zhu X, Ma T, Xu C, Zhangsun D, Yu J, Kaas Q, Harvey PJ, McIntosh JM, Craik DJ, Luo (2025). Selective Inhibition of Rat ¿7 Nicotinic Acetylcholine Receptors by LvID, a Newly Characterized ¿4/7-Conotoxin from Conus lividus. Journal of medicinal chemistry, 68(8), 8163-8173.
  7. Tekarli B, Azam L, Hone AJ, McIntosh J (2025). Human ¿10 nicotinic acetylcholine receptor subunits assemble to form functional receptors. The Journal of biological chemistry, 301(2), 108182.
  8. Williams BM, Steed ND, Woolley JT, Moedl AA, Nelson CA, Jones GC, Burris MD, Arias HR, Kim OH, Jang EY, Hone AJ, McIntosh JM, Yorgason JT, Steffensen S (2024). Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of ¿6-Nicotinic Receptors and Dopamine Transporters. ACS chemical neuroscience, 15(9), 1738-1754.
  9. Wang H, Li X, Qiao Y, Wang M, Wang W, McIntosh JM, Zhangsun D, Luo (2024). ¿O-Conotoxin GeXIVA[1,2] Reduced Neuropathic Pain and Changed Gene Expression in Chronic Oxaliplatin-Induced Neuropathy Mice Model. Marine drugs, 22(1),
  10. George AA, John SJ, Lucero LM, Eaton JB, Jaiswal E, Christensen SB, Gajewiak J, Watkins M, Cao Y, Olivera BM, Im W, McIntosh JM, Whiteaker (2024). Analogs of ¿-conotoxin PnIC selectively inhibit ¿7ß2- over ¿7-only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism. FASEB journal, 38(1), e23374.
  11. Neves JLB, Urcino C, Chase K, Dowell C, Hone AJ, Morgenstern D, Chua VM, Ramiro IBL, Imperial JS, Leavitt LS, Phan J, Fisher FA, Watkins M, Raghuraman S, Tun JO, Ueberheide BM, McIntosh JM, Vasconcelos V, Olivera BM, Gajewiak (2024). Using Constellation Pharmacology to Characterize a Novel ¿-Conotoxin from Conus ateralbus. Marine drugs, 22(3),
  12. Luo A, He J, Yu J, Wu Y, Harvey PJ, Kasheverov IE, Kudryavtsev DS, McIntosh JM, Tsetlin VI, Craik DJ, Zhangsun D, Luo (2024). Aspartic acid mutagenesis of ¿O-Conotoxin GeXIVA isomers reveals arginine residues crucial for inhibition of the ¿9¿10 nicotinic acetylcholine receptor. International journal of biological macromolecules, 271(Pt 1), 132472.
  13. Hone AJ, Santiago U, Harvey PJ, Tekarli B, Gajewiak J, Craik DJ, Camacho CJ, McIntosh J (2024). Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors. Journal of medicinal chemistry, 67(11), 9587-9598.
  14. Azam L, Christensen SB, Riaz Z, Kendell A, Cull J, Hone AJ, McIntosh J (2024). ¿9-Containing Nicotinic Acetylcholine Receptors Are Required for RgIA-5474 Attenuation of Chemotherapy-Induced Neuropathic Pain. ACS pharmacology & translational science, 7(12), 3935-3944.
  15. Jiménez-Pompa A, Arribas RL, McIntosh JM, Albillos (2023). Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of ¿7 versus ¿3ß4 nicotinic receptor subtypes in mouse hippocampal neurons. Biochemical and biophysical research communications, 684, 149115.
  16. Tae HS, Ortells MO, Tekarli BJ, Manetti D, Romanelli MN, McIntosh JM, Adams DJ, Arias H (2023). DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits ¿7 and ¿9¿10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms. ACS chemical neuroscience, 14(14), 2537-2547.
  17. Wu X, Hone AJ, Huang YH, Clark RJ, McIntosh JM, Kaas Q, Craik D (2023). Computational design of ¿-conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry (Weinheim an der Bergstrasse, Germany), e202302909.
  18. Wadsworth HA, Anderson EQ, Williams BM, Ronström JW, Moen JK, Lee AM, McIntosh JM, Wu J, Yorgason JT, Steffensen S (2023). Role of ¿6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens. Molecular neurobiology, 60(6), 3113-3129.
  19. Richter K, Papke RL, Stokes C, Roy DC, Espinosa ES, Wolf PMK, Hecker A, Liese J, Singh VK, Padberg W, Schlüter KD, Rohde M, McIntosh JM, Morley BJ, Horenstein NA, Grau V, Simard A (2022). Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP. Frontiers in cellular neuroscience, 16, 779081.
  20. Hone AJ, McIntosh J (2022). Alkaloid ligands enable function of homomeric human ¿10 nicotinic acetylcholine receptors. Frontiers in pharmacology, 13, 981760.
  21. Richter K, Papke RL, Stokes C, Roy DC, Espinosa ES, Wolf PMK, Hecker A, Liese J, Singh VK, Padberg W, Schlüter KD, Rohde M, McIntosh JM, Morley BJ, Horenstein NA, Grau V, Simard A (2022). Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP. Frontiers in cellular neuroscience, 16, 779081.
  22. Jiménez-Pompa A, Sanz-Lázaro S, Omodolor RE, Medina-Polo J, González-Enguita C, Blázquez J, McIntosh JM, Albillos (2022). Cross Talk between ¿7 and ¿3ß4 Nicotinic Receptors Prevents Their Desensitization in Human Chromaffin Cells. The Journal of neuroscience, 42(7), 1173-1183.
  23. Huynh PN, Christensen SB, McIntosh J (2022). RgIA4 Prevention of Acute Oxaliplatin-Induced Cold Allodynia Requires ¿9-Containing Nicotinic Acetylcholine Receptors and CD3(+) T-Cells. Cells, 11(22),
  24. Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou D (2021). Discovery of Methylene Thioacetal-Incorporated ¿-RgIA Analogues as Potent and Stable Antagonists of the Human ¿9¿10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain. Journal of medicinal chemistry, 64(13), 9513-9524.
  25. Gajewiak J, Christensen SB, Dowell C, Hararah F, Fisher F, Huynh PN, Olivera BM, McIntosh J (2021). Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism. Journal of medicinal chemistry, 64(13), 9271-9278.
  26. Fisher F, Zhang Y, Vincent PFY, Gajewiak J, Gordon TJ, Glowatzki E, Fuchs PA, McIntosh J (2021). Cy3-RgIA-5727 Labels and Inhibits ¿9-Containing nAChRs of Cochlear Hair Cells. Frontiers in cellular neuroscience, 15, 697560.
  27. Paguigan ND, Tun JO, Leavitt LS, Lin Z, Chase K, Dowell C, Deering-Rice CE, Lim AL, Karthikeyan M, Hughen RW, Zhang J, Peterson RT, Reilly CA, Light AR, Raghuraman S, McIntosh JM, Olivera BM, Schmidt E (2021). Nicotinic Acetylcholine Receptor Partial Antagonist Polyamides from Tunicates and Their Predatory Sea Slugs. ACS chemical neuroscience, 12(14), 2693-2704.
  28. Sethuramanujam S, Matsumoto A, deRosenroll G, Murphy-Baum B, Grosman C, McIntosh JM, Jing M, Li Y, Berson D, Yonehara K, Awatramani G (2021). Rapid multi-directed cholinergic transmission in the central nervous system. Nature communications, 12(1), 1374.
  29. Edinger F, Schmitt C, Koch C, McIntosh JM, Janciauskiene S, Markmann M, Sander M, Padberg W, Grau (2021). Application of alpha1-antitrypsin in a rat model of veno-arterial extracorporeal membrane oxygenation. Scientific reports, 11(1), 15849.
  30. Zheng N, Christensen SB, Blakely A, Dowell C, Purushottam L, McIntosh JM, Chou D (2020). Development of Conformationally Constrained ¿-RgIA Analogues as Stable Peptide Antagonists of Human ¿9¿10 Nicotinic Acetylcholine Receptors. Journal of medicinal chemistry, 63(15), 8380-8387.
  31. Hone AJ, Rueda-Ruzafa L, Gordon TJ, Gajewiak J, Christensen S, Dyhring T, Albillos A, McIntosh J (2020). Expression of ¿3ß2ß4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists. Journal of neurochemistry, 154(2), 158-176.
  32. Yu Z, McIntosh JM, Sadeghi SG, Glowatzki (2020). Efferent synaptic transmission at the vestibular type II hair cell synapse. Journal of neurophysiology, 124(2), 360-374.
  33. Donvito G, Muldoon PP, Jackson KJ, Ahmad U, Zaveri NT, McIntosh JM, Chen X, Lichtman AH, Damaj M (2020). Neuronal nicotinic acetylcholine receptors mediate ¿9 -THC dependence: Mouse and human studies. Addiction biology, 25(1), e12691.
  34. Rybin MJ, O'Brien H, Ramiro IBL, Azam L, McIntosh JM, Olivera BM, Safavi-Hemami H, Yoshikami (2020). ¿M-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish. Toxins, 12(3),
  35. Toma W, Ulker E, Alqasem M, AlSharari SD, McIntosh JM, Damaj M (2020). Behavioral and Molecular Basis of Cholinergic Modulation of Pain: Focus on Nicotinic Acetylcholine Receptors. Current topics in behavioral neurosciences, 45, 153-166.
  36. Richter K, Ogiemwonyi-Schaefer R, Wilker S, Chaveiro AI, Agné A, Hecker M, Reichert M, Amati AL, Schlüter KD, Manzini I, Schmalzing G, McIntosh JM, Padberg W, Grau V, Hecker (2020). Amyloid Beta Peptide (Aß1-42) Reverses the Cholinergic Control of Monocytic IL-1ß Release. Journal of clinical medicine, 9(9),
  37. Bjørn-Yoshimoto WE, Ramiro IBL, Yandell M, McIntosh JM, Olivera BM, Ellgaard L, Safavi-Hemami (2020). Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research. Biomedicines, 8(8),
  38. Peng C, Yan Y, Kim VJ, Engle SE, Berry JN, McIntosh JM, Neve RL, Drenan R (2019). Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission. The European journal of neuroscience, 50(3), 2224-2238.
  39. Hone AJ, Fisher F, Christensen S, Gajewiak J, Larkin D, Whiteaker P, McIntosh J (2019). PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets ¿3ß2 Nicotinic Acetylcholine Receptors. Journal of medicinal chemistry, 62(13), 6262-6275.
  40. van Hout M, Valdes A, Christensen SB, Tran PT, Watkins M, Gajewiak J, Jensen AA, Olivera BM, McIntosh J (2019). ¿-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of ¿6ß4* nicotinic acetylcholine receptors. Neuropharmacology, 157, 107691.
  41. Huynh PN, Giuvelis D, Christensen S, Tucker KL, McIntosh J (2019). RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats. Marine drugs, 18(1),
  42. Arribas-Blázquez M, Olivos-Oré LA, Barahona MV, Sánchez de la Muela M, Solar V, Jiménez E, Gualix J, McIntosh JM, Ferrer-Montiel A, Miras-Portugal MT, Artalejo A (2019). Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. International journal of molecular sciences, 20(1),
  43. Grau V, Richter K, Hone AJ, McIntosh J (2019). Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes. Frontiers in pharmacology, 9, 1499.
  44. Zakrzewicz A, Richter K, Zakrzewicz D, Siebers K, Damm J, Agné A, Hecker A, McIntosh JM, Chamulitrat W, Krasteva-Christ G, Manzini I, Tikkanen R, Padberg W, Janciauskiene S, Grau (2019). SLPI Inhibits ATP-Mediated Maturation of IL-1ß in Human Monocytic Leukocytes: A Novel Function of an Old Player. Frontiers in immunology, 10, 664.
  45. Hone AJ, Talley TT, Bobango J, Huidobro Melo C, Hararah F, Gajewiak J, Christensen S, Harvey PJ, Craik DJ, McIntosh J (2018). Molecular determinants of ¿-conotoxin potency for inhibition of human and rat ¿6ß4 nicotinic acetylcholine receptors. The Journal of biological chemistry, 293(46), 17838-17852.
  46. Bavo F, Pucci S, Fasoli F, Lammi C, Moretti M, Mucchietto V, Lattuada D, Viani P, De Palma C, Budriesi R, Corradini I, Dowell C, McIntosh JM, Clementi F, Bolchi C, Gotti C, Pallavicini (2018). Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an ¿7-nAChR, ¿9-nAChR Antagonist and of a Pro-Oxidant Mitocan. Journal of medicinal chemistry, 61(23), 10531-10544.
  47. Chen DJ, Gao FF, Ma XK, Shi GG, Huang YB, Su QX, Sudweeks S, Gao M, Dharshaun T, Eaton JB, Chang YC, Mcintosh JM, Lukas RJ, Whiteaker P, Steffensen SC, Wu (2018). Pharmacological and functional comparisons of ¿6/¿3ß2ß3-nAChRs and ¿4ß2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line. Acta pharmacologica Sinica, 39(10), 1571-1581.
  48. Richter K, Koch C, Perniss A, Wolf PM, Schweda EKH, Wichmann S, Wilker S, Magel I, Sander M, McIntosh JM, Padberg W, Grau (2018). Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1ß Release by Pulmonary Epithelial Cells. Molecules (Basel, Switzerland), 23(8),
  49. Richter K, Sagawe S, Hecker A, Küllmar M, Askevold I, Damm J, Heldmann S, Pöhlmann M, Ruhrmann S, Sander M, Schlüter KD, Wilker S, König IR, Kummer W, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz AT, Koch C, Grau (2018). C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation. Frontiers in immunology, 9, 1604.
  50. Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau (2018). Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1ß via CD36 and Nicotinic Acetylcholine Receptors. Frontiers in immunology, 9, 877.
  51. Yan Y, Peng C, Arvin MC, Jin XT, Kim VJ, Ramsey MD, Wang Y, Banala S, Wokosin DL, McIntosh JM, Lavis LD, Drenan R (2018). Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission. Cell reports, 23(8), 2236-2244.
  52. Mucchietto V, Fasoli F, Pucci S, Moretti M, Benfante R, Maroli A, Di Lascio S, Bolchi C, Pallavicini M, Dowell C, McIntosh M, Clementi F, Gotti (2018). ¿9- and ¿7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line. British journal of pharmacology, 175(11), 1957-1972.
  53. Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM, McIntosh J (2017). Inhibition of ¿9¿10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America, 114(10), E1825-E1832.
  54. Pang X, Liu L, Ngolab J, Zhao-Shea R, McIntosh JM, Gardner PD, Tapper A (2016). Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors. Neuropharmacology, 107, 294-304.
  55. Baladi MG, Nielsen SM, McIntosh JM, Hanson GR, Fleckenstein A (2016). Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. Behavioural pharmacology, 27(5), 422-30.
  56. Zhang D, McGregor M, Bordia T, Perez XA, McIntosh JM, Decker MW, Quik (2015). ¿7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage. Movement disorders, 30(14), 1901-1911.
  57. Grady SR, Meinerz NM, Cao J, Reynolds AM, Picciotto MR, Changeux JP, McIntosh JM, Marks MJ, Collins A (2001). Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. Journal of neurochemistry, 76(1), 258-68.

Review

  1. Pei S, Wang N, Mei Z, Zhangsun D, Craik DJ, McIntosh JM, Zhu X, Luo (2024). Conotoxins Targeting Voltage-Gated Sodium Ion Channels. Pharmacological reviews, 76(5), 828-845.
  2. Hone AJ, McIntosh J (2023). Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation. Pharmacological research, 190, 106715.
  3. Margiotta F, Micheli L, Ciampi C, Ghelardini C, McIntosh JM, Di Cesare Mannelli (2022). Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism. Marine drugs, 20(12),

Other

  1. Sethuramanujam S, Matsumoto A, deRosenroll G, Murphy-Baum B, Grosman C, McIntosh JM, Jing M, Li Y, Berson D, Yonehara K, Awatramani G (2021). Author Correction: Rapid multi-directed cholinergic transmission in the central nervous system. Nature communications, 12(1), 2441.

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