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K.C. Brennan
( out of 391 reviews )

K.C. Brennan, MD

Languages spoken: French, Portuguese, English, Spanish

Clinical Locations

Primary Location

Imaging and Neurosciences Center

Headache Clinic
729 Arapeen Way
Salt Lake City , UT 84108

K.C. Brennan, MD, is a clinician scientist who specializes in the treatment of headache. disorders. His lab studies the basic mechanisms of migraine and post-traumatic headache. See more about his lab.

You can also view his:

Board Certification

American Board of Psychiatry & Neurology (Neurology)
United Council for Neurologic Subspecialties (Headache Medicine)

Patient Rating

Patients describe Dr. Brennan as exceptionally caring, kind, and personable, with a warm bedside manner and a habit of remembering individual patients. Reviewers highlight his strong knowledge of migraines and related treatments, his thorough explanations, and his habit of involving patients in decision-making to tailor care that improves quality of life. Many comments also praise his technical skill and professionalism with procedures like Botox and nerve blocks, and say he makes them feel heard, supported, and confident in their care.

Generated via Patient Reviews

5.0 /5
( out of 391 reviews )

The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers. The scale on which responses are measured is 1 to 5 with 5 being the best score.


May 18, 2026
CLINICAL NEUROSCIENCES CENTER

Dr Brennan always involves me in the decision making & treatment plan. He always follows up on how things have gone since my last appointment. He showed concern & explained issued that had occurred regarding the authorization process to get my treatment approved,

May 03, 2026
CLINICAL NEUROSCIENCES CENTER

Always very thorough and kind and knowledgeable.

Apr 26, 2026
CLINICAL NEUROSCIENCES CENTER

Dr Kevin Brennan is a great doctor working with issues with my migraine headaches and other issues that go along with the migraines

Apr 07, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Brennan is incredibly compassionate and helps keep me motivated even though I'm facing the largest mountains I've ever had to traverse. I feel more confident managing my conditions when I talk to him during my Botox treatments. He's also amazing at Botox treatment.

Mar 30, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Brennan is amazing, he takes the time to really get to know you and know what your needs are within the procedures that he provides. I wouldn't keep coming back to him every four weeks for my nerve blocks if I didn't feel comfortable with his abilities and professionalism

Mar 19, 2026
CLINICAL NEUROSCIENCES CENTER

Dr Brennan has been treating my migraines for a long while. I can honestly say before him I had stopped believing that anything would help. Migraines are always changing, at least for me. Dr Brennan is stuck to there is only one way to treat them. Every visit we talk about new treatments, not only medical but also lifestyle changes. He keeps up to date on research and his knowledge proves this. One in a million, I will say this all the time!

Mar 16, 2026
CLINICAL NEUROSCIENCES CENTER

Bedside manner is out of this world! Seems to really care about you and your issues..and why you are there to see him.

Mar 03, 2026
CLINICAL NEUROSCIENCES CENTER

Very personable and thorough. Great M.D.

Mar 02, 2026
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is the best, most caring doctor EVER!!

Feb 09, 2026
CLINICAL NEUROSCIENCES CENTER

He's always looking for new ways to help me. He always listens more and takes the time to understand ways to help me with things I would help me. He's totally committed to work with other drs. Greatest Dr!

Jan 25, 2026
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is very professional and knows alot about migraine headaches

Dec 07, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is AMAZING! I cannot believe I have been so lucky to find him as a provider. His knowledge to treat my migraines and the many things that can contribute to them is mind blowing. Yet, this is not the most amazing part of his care. His genuine care about me as a person is something you only find in very few providers. Something I am sure he believes is just a given is extremely rare. I cannot thank him enough. I could go on and on about how caring he is. I cannot say enough! Thank you Dr Brennan!!!

Nov 25, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is top notch and there aren't enough words to describe him. He actually listens to all my concerns, and his wisdom and personality can not be replaced. I absolutely love Dr.Brennan!

Nov 24, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Brennan is an excellent doctor. Don't ever hesitate to use him for all your needs. Dr. Brennan and staff are all top notch and very professional. I drive quite a ways just to come to Dr. Brennan. I highly recommend this clinic and Dr. Brennan.

Nov 10, 2025
CLINICAL NEUROSCIENCES CENTER

Awesome physician!!

Oct 26, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is the absolute BEST! He gives the most excellent care and makes me feel as if I am his most important patient. He is my most favorite doctor of all time.

Oct 12, 2025
CLINICAL NEUROSCIENCES CENTER

Very kind doctor, thorough and very attentive.

Sep 07, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is kind & professional. He is attentive to your needs & health. He always makes sure you understand your treatment & answers your questions. You never feel like you are being rushed through the clinic

Aug 25, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Brennan is a very good doctor. He is efficient and cares a great deal about his patients including me. I like him a lot, and I would recommend him to my family and friends without worry.

Aug 17, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Brennan is an exceptional doctor. He has knowledge compassion and is thorough with his patience. I would recommend him time and time again.

Aug 11, 2025
CLINICAL NEUROSCIENCES CENTER

He's very caring and amazing

Jul 15, 2025
CLINICAL NEUROSCIENCES CENTER

He is an amazing doctor, he knows how to deliver care in a kind and timely manner which is great when you have about 25 shots! He is such a good person.

Jul 06, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is kind, personable and he listens. He is understanding and genuinely wants to help you feel better. He always remembers you and what's going on in your life. He is very knowledgeable and I feel he is always striving to making his patients quality of life with getting to the bottom of your health issues. One of the best doctors I have gone to!

Jun 23, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Brennan has been very good to me. He understands the issues I'm dealing with and gives me options for treatments. He is caring, knowledgeable and compassionate.

Jun 09, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is always engaging & has me participate in decision making. He remembers me from previous appointments & treats me like family. He answers my questions & explains what he is doing & why.

May 27, 2025
CLINICAL NEUROSCIENCES CENTER

Fabulous provider.

May 26, 2025
CLINICAL NEUROSCIENCES CENTER

I cannot praise Dr Brennan enough! Dr Brennan doesn't only concentrates on the Botox alone to help relieve some of my migraines. Durinrg my visits we discuss other areas that I can practice such as yoga, self care, etc, Along with the Botox to relieve my breakthrough migraines. He often takes the time after my appointments to send me any resources that he may have to practice these areas. Dr Brennan is simply amazing!

May 26, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is a great doctor and very professional. He is always on time. I have only good things to say about him.

May 12, 2025
CLINICAL NEUROSCIENCES CENTER

Very caring and helpful. How desire to improve the quality of the life of his patients makes all the difference.

May 11, 2025
CLINICAL NEUROSCIENCES CENTER

He's a great doctor and very caring. Amazing

Apr 27, 2025
CLINICAL NEUROSCIENCES CENTER

Great doctor, he knows what he's doing and is very skilled . He also will listen if I have concerns and will give guidance if needed.

Mar 30, 2025
CLINICAL NEUROSCIENCES CENTER

He is fabulous! He is very caring and kind with his patients.

Mar 23, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Brennan is the quintessential provider. He is extremely knowledgeable, takes all the time I need to explain my current health situation, treatment, and any future follow up I might need. He is very kind and gentle, and makes sure I have all my questions and medical needs met! I will be forever grateful for his wonderful care, and would highly recommend him to family and friends alike.

Mar 10, 2025
CLINICAL NEUROSCIENCES CENTER

Very kind and gentle. Great at giving Botox injections for migraine headache prevention.

Feb 24, 2025
CLINICAL NEUROSCIENCES CENTER

Kevin has been a great and very helpful doctor.

Feb 11, 2025
CLINICAL NEUROSCIENCES CENTER

He is very knowledgeable and friendly.

Feb 03, 2025
CLINICAL NEUROSCIENCES CENTER

Dr.Brennan is one of the best. I can't recommend him enough.

Dec 29, 2024
IMAGING AND NEUROSCIENCES CENTER

Amazing

Dec 16, 2024
IMAGING AND NEUROSCIENCES CENTER

He is a kind, extremely knowledgeable practitioner, who listens and cares about you as a person. They do not make them like him anymore!

Nov 11, 2024
CLINICAL NEUROSCIENCES CENTER

He is always friendly and upbeat.

Oct 20, 2024
CLINICAL NEUROSCIENCES CENTER

Dr Brennan is an amazing doctor. Easy to talk to. Cares about his patients, and truly wants the best for them. Tailors treatments to what will help the patient the most. Absolutely worth traveling to see him.


Patient comments are gathered from our patient experience survey and displayed in their entirety. For the convenience of our visitors, some patient comments have been translated from their original language into English while preserving their original meaning as accurately as possible. Patients are de-identified for confidentiality and patient privacy.

Board Certification and Academic Information

Academic Departments Neurobiology -Adjunct Professor
Neurology -Professor
Board Certification
American Board of Psychiatry & Neurology (Neurology)
United Council for Neurologic Subspecialties (Headache Medicine)

Education history

Undergraduate School of Foreign Service - Georgetown University B.A.
Certification Post-Baccalaureate Pre-Medical Sciences - Georgetown University Certificate
Professional Medical Medicine - Columbia University College of Physicians and Surgeons M.D.
Internship Internal Medicine - George Washington University Medical Center Intern
Residency Neurology - David Geffen School of Medicine at UCLA Resident
Fellowship Headache, Neurophysiology - David Geffen School of Medicine at UCLA, Department of Neurology Fellow
Other Training Imaging Structure and Function in the Nervous System - Cold Spring Harbor Laboratory Summer Course

Selected Publications

Journal Article

  1. Cortez MM, Millsap L, Brennan KC, Campbell C (2019). Craniofacial Autonomic Dysfunction in Migraine: Implications for Treatment and Prognosis. Journal of neuro-ophthalmology, 40(1), 67-73.
  2. Chung LS, Brennan KC, Rolston J (2019). Early Focal Brain Injury Predicts Spreading Depolarizations after Subarachnoid Hemorrhage. Neurosurgery, 85(2), E188-E189.
  3. Shuttleworth CW, Andrew RD, Akbari Y, Ayata C, Balu R, Brennan KC, Boutelle M, Carlson AP, Dreier JP, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell SL, Jones SC, Kirov SA, Lindquist BE, Maciel CB, Okonkwo D, Reinhart KM, Robertson RM, Rosenthal ES, Watanabe T, Hartings J (2019). Which Spreading Depolarizations Are Deleterious To Brain Tissue?. Neurocritical care,
  4. Pietrobon D, Brennan K (2019). Genetic mouse models of migraine. The journal of headache and pain, 20(1), 79.
  5. Cortez MM, Rae N, Millsap L, McKean N, Brennan K (2019). Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache. Frontiers in neurology, 10, 478.
  6. Sawant-Pokam PM, Suryavanshi P, Mendez JM, Dudek FE, Brennan K (2017). Mechanisms of Neuronal Silencing After Cortical Spreading Depression. Cerebral cortex (New York, N.Y., 27(2), 1311-1325.
  7. Kaufmann D, Bates EA, Yagen B, Bialer M, Saunders GH, Wilcox K, White HS, Brennan K (2016). sec-Butylpropylacetamide (SPD) has antimigraine properties. Cephalalgia, 36(10), 924-35.
  8. Bogdanov VB, Middleton NA, Theriot JJ, Parker PD, Abdullah OM, Ju YS, Hartings JA, Brennan K (2016). Susceptibility of Primary Sensory Cortex to Spreading Depolarizations. The Journal of neuroscience, 36(17), 4733-43.
  9. Kinard KI, Smith AG, Singleton JR, Lessard MK, Katz BJ, Warner JE, Crum AV, Mifflin MD, Brennan KC, Digre K (2015). Chronic migraine is aaociated with reduced corneal nerve fiber density and symptoms of dry eye. Headache, 55(4), 543-9.
  10. Tang YT, Mendez JM, Theriot JJ, Sawant PM, López-Valdés HE, Ju YS, Brennan K (2014). Minimum conditions for the induction of cortical spreading depression in brain slices. Journal of neurophysiology, 112(10), 2572-9.
  11. Lopez-Valdes HE, Clarkson AN, Ao Y, Charles AC, Carmichael ST, Sofroniew MV, Brennan K (2014). Memantine enhances recovery from stroke. Stroke, 45(7), 2093-100.
  12. Bogdanov VB, Bogdanov OV, Koulchitsky SV, Chauvel V, Multon S, Makarchuk MY, Brennan KC, Renshaw PF., Schoenen J. (01/01/2013). Behavior in the open field predicts the number of KCl-induced cortical spreading depression in rats. Behav Brain Res, 236, 90 - 93.
  13. Clarkson AN, Lopez-Valdes HE, Overmann JJ, Charles AC, Brennan KC, Thomas Carmichael S (2013). Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model. Journal of cerebral blood flow and metabolism, 33(5), 716-723.
  14. Chang J, Brennan K, He D, Huang H, Miura R, Wilson P, Wylie (2013). A Mathematical Model of the Metabolic and Perfusion Effects on Cortical Spreading Depression. PloS one,
  15. Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptacek LJ (2013). Casein kinase 1 delta mutations in familial migraine and advanced sleep phase. Science translational medicine, 1(5), 1-11.
  16. Ahn AH, Brennan K (2012). Unanswered questions in headache: how does a migraine attack stop?. Headache, 52(1), 186-7.
  17. Theriot JJ, Toga AW, Prakash N, Ju, YS, Brennan K (2012). Cortical sensory plasticity in a model of migraine with aura. The Journal of neuroscience, 32(44), 15252-61.
  18. Chang JC, Brennan KC, Chou (2011). Tracking monotonically advancing boundaries in image sequences using graph cuts and recursive kernel shape priors. IEEE transactions on medical imaging, PMC2215697,
  19. Tang YT, Kim J, Lopez-Valdes HE, Brennan KC, Ju Y (2011). Development and characterization of a microfluidic chamber incorporating fluid ports with active suction for localized chemical stimulation of brain slices. Lab on a chip, 11(13), 2247-54.
  20. Chang JC, Shook LL, Biag J, Nguyen EN, Toga AW, Charles AC, Brennan K (2010). Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression. Brain, 133(Pt 4), 996-1012.
  21. Bates EA, Nikai T, Brennan KC, Fu YH, Charles AC, Basbaum AI, Ptacek LJ, Ahn A (2010). Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia, 30(2), 170-8.
  22. Lopez-Valdes HE, Beltran-Parrazal L, Brennan KC, Charles A (2010). Bradykinin increases resensitization of purinergic receptor signaling in glioma cells. Cancer cell international, 10, 35.
  23. Brennan KC, Romero Reyes M, Lopez Valdes HE, Arnold AP, Charles AC (2007). Reduced threshold for cortical spreading depression in female mice. Ann Neurol, 61(6), 603-6.
  24. Brennan KC, Beltran-Parrazal L, Lopez-Valdes HE, Theriot J, Toga AW, Charles A (2007). Distinct vascular conduction with cortical spreading depression. Journal of neurophysiology, 97(6), 4143-51.
  25. Charles A, Flippen C, Romero Reyes M, Brennan K (2007). Memantine for prevention of migraine: a retrospective study of 60 cases. The journal of headache and pain, 8(4), 248-50.
  26. Beltran-Parrazal L, López-Valdés HE, Brennan KC, Díaz-Muñoz M, de Vellis J, Charles AC (2006). Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium. American journal of physiology. Cell physiology, 291(6), C1193-7.
  27. Brennan KC, Jurewicz EC, Ford B, Pullman SL, Louis E (2002). Is essential tremor predominantly a kinetic or a postural tremor? A clinical and electrophysiological study. Movement disorders, 17(2), 313-6.
  28. Sakai N, Brennan K, Weiss L, Matile (1997). Toward Biomimetic Ion Channels Formed by Rigid-Rod Molecules: Length-Dependent Ion-Transport Activity of Oligo(p-Phenylene)s. Journal of the American Chemical Society, 119, 8726-8727.

Review

  1. Digre KB, Brennan K (2012). Shedding light on photophobia. Journal of neuro-ophthalmology, 32(1), 68-81.
  2. Brennan KC, Charles (2010). An update on the blood vessel in migraine. Current opinion in neurology, 23(3), 266-74.
  3. Charles A, Brennan K (2010). The neurobiology of migraine. Handbook of clinical neurology, 97, 99-108.
  4. Charles A, Brennan (2009). Cortical spreading depression-new insights and persistent questions. Cephalalgia, 29(10), 1115-24.
  5. Brennan KC, Charles (2009). Sleep and headache. Seminars in neurology, 29(4), 406-18.
  6. Matsumoto J, Saver JL, Brennan KC, Ringman JM (2005). Mitochondrial encephalomyopathy with lactic acidosis and stroke (MELAS). Reviews in neurological diseases, 2(1), 30-4.

Book Chapter

  1. Charles A, Brennan K (2010). The neurobiology of migraine. Handbook of clinical neurology, 97, 99-108.
  2. Brennan KC, Toga A (2009). Intraoperative optical imaging.
  3. CharlesAC, Brennan K (2008). Glial cell calcium signaling.
  4. Brennan KC, Charles A (2008). Mechanisms of cortical spreading depression as targets for migraine therapy.

Editorial

  1. Brennan KC, Ahn A (2013). Unanswered questions in headache: So what is photophobia, anyway?. Headache, 53(10), 1673-4.
  2. Brennan K (2011). Turn down the lights! An irritable occipital cortex in migraine without aura. Neurology, 76(3), 206-7.
  3. Charles A, Brennan KC (2008). A touch of increased pain: cutaneous allodynia in migraine. Ann Neurol, 63(2), 130-2.
  4. Charles A, Brennan K (2007). Sumatriptan-naproxen combination for acute migraine. Nature clinical practice. Neurology, 3(11), 604-5.

Abstract

  1. Lopez-Valdes HE, Clarkson AN, Carmichael ST, Charles AC, Brennan K (2009). Chronic treatment with memantine enhances recovery of somatosensory maps in a mouse stroke model. Annual Meeting of the Society for Neuroscience, Chicago, IL.
  2. Brennan KC, Chang J, Shook L, Biag J, Nguyen E, Toga AW, Charles AC (2009). Biphasic DC shift, hemoglobin desaturation, and neurovascular uncoupling in cortical spreading depression. 134th Annual Meeting of the American Neurological Association, Baltimore MD. Selected for Platform Presentation.
  3. Lopez-Valdes HE, Biag J, Chang J, Toga AW, Charles AC, Brennan K (2008). Long term optical intrinsic signal imaging of forepaw and hindpaw cortex in mouse. Annual Meeting of the Society for Neuroscience, Washington, DC.
  4. Chang J, Shook L, Charles AC, Brennan K (2008). Significant hemoglobin desaturation during cortical spreading depression. 133rd Annual Meeting of the American Neurological Association, Salt Lake City UT.
  5. Brennan KC, Romero Reyes M, Lopez-Valdes HE, Arnold AP, Charles A (2007). Reduced threshold for cortical spreading depression in female mice. 13th Annual Congress of the International Headache Society, Stockholm, Sweden.
  6. K.C. Brennan, Hector E. López-Valdés, Marcela Romero Reyes, Arthur P Arnold, Andrew C. Charles (2007). Reduced threshold for cortical spreading depression in female mice. American Headache Society Annual Scientific Meeting, Chicago IL. Selected for Platform Presentation.
  7. Brennan KC, Shapiro RE, Xu Y, Ptacek LJ, Fu YH, Charles A (2006). Alterations in spreading depression in a transgenic mouse carrying a novel potential migraine gene. (Selected for Platform Presentation, awarded Best Poster Prize), Migraine Trust International Symposium, London, UK.
  8. KC Brennan, Ying Xu, Louis Ptácek, and Andrew Charle (2006). Reduced threshold for cortical spreading depression in mice expressing CK1dT44A. Channels, Receptors, and Synapses Meeting. Cold Spring Harbor NY. Selected for Platform Presentation.
  9. KC Brennan, Robert Shapiro, Louis Ptácek, and Andrew Charle (2006). Reduced threshold for cortical spreading depression and increased vasodilatation in mice expressing CK1dT44A. American Headache Society Annual Scientific Meeting, Los Angeles CA. Selected for Platform Presentation.
  10. KC Brennan, Jeremy Theriot, Kevin Cury, Arthur W. Toga, Andrew C. Charles (2005). Changes in arterial caliber can precede cortical spreading depression. 12th Annual Congress of the International Headache Society, Kyoto, Japan. Selected for Platform Presentation.
  11. Brennan KC, Guiou M, Cury K, Prakash N, Toga A, Charles A (2004). Flufenamic acid prevents optical intrinsic signal changes associated with spreading depression. UCLA Joint Neurology Residency and Postdoctoral Research Symposium.

Other

  1. Brennan K, Digre K, Baggaley (2012). Headache- A Patient's Guide.