K.C. Brennan, MD

Journal Article

1. Brennan KC, Romero Reyes M, Lopez Valdes HE, Arnold AP, Charles AC (2007). Reduced threshold for cortical spreading depression in female mice. Ann Neurol, 61(6), 603-6. (Read full publication)
2. Bogdanov VB, Bogdanov OV, Koulchitsky SV, Chauvel V, Multon S, Makarchuk MY, Brennan KC, Renshaw PF., Schoenen J. (01/01/2013). Behavior in the open field predicts the number of KCl-induced cortical spreading depression in rats. Behav Brain Res, 236, 90 - 93.
3. Chang JC, Shook LL, Biag J, Nguyen EN, Toga AW, Charles AC, Brennan K (2010). Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression. Brain, 133(Pt 4), 996-1012. (Read full publication)
4. Sawant-Pokam PM, Suryavanshi P, Mendez JM, Dudek FE, Brennan K (2017). Mechanisms of Neuronal Silencing After Cortical Spreading Depression. Cerebral cortex (New York, N.Y., 27(2), 1311-1325. (Read full publication)
5. Cortez MM, Millsap L, Brennan KC, Campbell C (2019). Craniofacial Autonomic Dysfunction in Migraine: Implications for Treatment and Prognosis. Journal of neuro-ophthalmology, 40(1), 67-73. (Read full publication)
6. Bates EA, Nikai T, Brennan KC, Fu YH, Charles AC, Basbaum AI, Ptacek LJ, Ahn A (2010). Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia, 30(2), 170-8. (Read full publication)
7. Kaufmann D, Bates EA, Yagen B, Bialer M, Saunders GH, Wilcox K, White HS, Brennan K (2016). sec-Butylpropylacetamide (SPD) has antimigraine properties. Cephalalgia, 36(10), 924-35. (Read full publication)
8. Ahn AH, Brennan K (2012). Unanswered questions in headache: how does a migraine attack stop?. Headache, 52(1), 186-7.
9. Kinard KI, Smith AG, Singleton JR, Lessard MK, Katz BJ, Warner JE, Crum AV, Mifflin MD, Brennan KC, Digre K (2015). Chronic migraine is aaociated with reduced corneal nerve fiber density and symptoms of dry eye. Headache, 55(4), 543-9.
10. Sakai N, Brennan K, Weiss L, Matile (1997). Toward Biomimetic Ion Channels Formed by Rigid-Rod Molecules: Length-Dependent Ion-Transport Activity of Oligo(p-Phenylene)s. Journal of the American Chemical Society, 119, 8726-8727.
11. Clarkson AN, Lopez-Valdes HE, Overmann JJ, Charles AC, Brennan KC, Thomas Carmichael S (2013). Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model. Journal of cerebral blood flow and metabolism, 33(5), 716-723.
12. Brennan KC, Beltran-Parrazal L, Lopez-Valdes HE, Theriot J, Toga AW, Charles A (2007). Distinct vascular conduction with cortical spreading depression. Journal of neurophysiology, 97(6), 4143-51. (Read full publication)
13. Tang YT, Mendez JM, Theriot JJ, Sawant PM, López-Valdés HE, Ju YS, Brennan K (2014). Minimum conditions for the induction of cortical spreading depression in brain slices. Journal of neurophysiology, 112(10), 2572-9. (Read full publication)
14. Bogdanov VB, Middleton NA, Theriot JJ, Parker PD, Abdullah OM, Ju YS, Hartings JA, Brennan K (2016). Susceptibility of Primary Sensory Cortex to Spreading Depolarizations. The Journal of neuroscience, 36(17), 4733-43. (Read full publication)
15. Theriot JJ, Toga AW, Prakash N, Ju, YS, Brennan K (2012). Cortical sensory plasticity in a model of migraine with aura. The Journal of neuroscience, 32(44), 15252-61.
16. Brennan KC, Jurewicz EC, Ford B, Pullman SL, Louis E (2002). Is essential tremor predominantly a kinetic or a postural tremor? A clinical and electrophysiological study. Movement disorders, 17(2), 313-6. (Read full publication)
17. Chung LS, Brennan KC, Rolston J (2019). Early Focal Brain Injury Predicts Spreading Depolarizations after Subarachnoid Hemorrhage. Neurosurgery, 85(2), E188-E189. (Read full publication)
18. Lopez-Valdes HE, Clarkson AN, Ao Y, Charles AC, Carmichael ST, Sofroniew MV, Brennan K (2014). Memantine enhances recovery from stroke. Stroke, 45(7), 2093-100.
19. Chang JC, Brennan KC, Chou (2011). Tracking monotonically advancing boundaries in image sequences using graph cuts and recursive kernel shape priors. IEEE transactions on medical imaging, PMC2215697,
20. Beltran-Parrazal L, López-Valdés HE, Brennan KC, Díaz-Muñoz M, de Vellis J, Charles AC (2006). Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium. American journal of physiology. Cell physiology, 291(6), C1193-7.
21. Lopez-Valdes HE, Beltran-Parrazal L, Brennan KC, Charles A (2010). Bradykinin increases resensitization of purinergic receptor signaling in glioma cells. Cancer cell international, 10, 35. (Read full publication)
22. Tang YT, Kim J, Lopez-Valdes HE, Brennan KC, Ju Y (2011). Development and characterization of a microfluidic chamber incorporating fluid ports with active suction for localized chemical stimulation of brain slices. Lab on a chip, 11(13), 2247-54. (Read full publication)
23. Shuttleworth CW, Andrew RD, Akbari Y, Ayata C, Balu R, Brennan KC, Boutelle M, Carlson AP, Dreier JP, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell SL, Jones SC, Kirov SA, Lindquist BE, Maciel CB, Okonkwo D, Reinhart KM, Robertson RM, Rosenthal ES, Watanabe T, Hartings J (2019). Which Spreading Depolarizations Are Deleterious To Brain Tissue?. Neurocritical care, (Read full publication)
24. Charles A, Flippen C, Romero Reyes M, Brennan K (2007). Memantine for prevention of migraine: a retrospective study of 60 cases. The journal of headache and pain, 8(4), 248-50. (Read full publication)
25. Pietrobon D, Brennan K (2019). Genetic mouse models of migraine. The journal of headache and pain, 20(1), 79. (Read full publication)
26. Chang J, Brennan K, He D, Huang H, Miura R, Wilson P, Wylie (2013). A Mathematical Model of the Metabolic and Perfusion Effects on Cortical Spreading Depression. PloS one,
27. Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptacek LJ (2013). Casein kinase 1 delta mutations in familial migraine and advanced sleep phase. Science translational medicine, 1(5), 1-11.
28. Cortez MM, Rae N, Millsap L, McKean N, Brennan K (2019). Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache. Frontiers in neurology, 10, 478. (Read full publication)

Review

1. Brennan KC, Charles (2010). An update on the blood vessel in migraine. Current opinion in neurology, 23(3), 266-74. (Read full publication)
2. Digre KB, Brennan K (2012). Shedding light on photophobia. Journal of neuro-ophthalmology, 32(1), 68-81.
3. Charles A, Brennan (2009). Cortical spreading depression-new insights and persistent questions. Cephalalgia, 29(10), 1115-24. (Read full publication)
4. Brennan KC, Charles (2009). Sleep and headache. Seminars in neurology, 29(4), 406-18. (Read full publication)
5. Matsumoto J, Saver JL, Brennan KC, Ringman JM (2005). Mitochondrial encephalomyopathy with lactic acidosis and stroke (MELAS). Reviews in neurological diseases, 2(1), 30-4.
6. Charles A, Brennan K (2010). The neurobiology of migraine. Handbook of clinical neurology, 97, 99-108. (Read full publication)

Book Chapter

1. Charles A, Brennan K (2010). The neurobiology of migraine. Handbook of clinical neurology, 97, 99-108.
2. CharlesAC, Brennan K (2008). Glial cell calcium signaling.
3. Brennan KC, Charles A (2008). Mechanisms of cortical spreading depression as targets for migraine therapy.
4. Brennan KC, Toga A (2009). Intraoperative optical imaging.

Editorial

1. Charles A, Brennan KC (2008). A touch of increased pain: cutaneous allodynia in migraine. Ann Neurol, 63(2), 130-2. (Read full publication)
2. Brennan KC, Ahn A (2013). Unanswered questions in headache: So what is photophobia, anyway?. Headache, 53(10), 1673-4.
3. Brennan K (2011). Turn down the lights! An irritable occipital cortex in migraine without aura. Neurology, 76(3), 206-7.
4. Charles A, Brennan K (2007). Sumatriptan-naproxen combination for acute migraine. Nature clinical practice. Neurology, 3(11), 604-5. (Read full publication)

Abstract

1. Brennan KC, Guiou M, Cury K, Prakash N, Toga A, Charles A (2004). Flufenamic acid prevents optical intrinsic signal changes associated with spreading depression. UCLA Joint Neurology Residency and Postdoctoral Research Symposium.
2. Brennan KC, Shapiro RE, Xu Y, Ptacek LJ, Fu YH, Charles A (2006). Alterations in spreading depression in a transgenic mouse carrying a novel potential migraine gene. (Selected for Platform Presentation, awarded Best Poster Prize), Migraine Trust International Symposium, London, UK.
3. Brennan KC, Romero Reyes M, Lopez-Valdes HE, Arnold AP, Charles A (2007). Reduced threshold for cortical spreading depression in female mice. 13th Annual Congress of the International Headache Society, Stockholm, Sweden.
4. Lopez-Valdes HE, Biag J, Chang J, Toga AW, Charles AC, Brennan K (2008). Long term optical intrinsic signal imaging of forepaw and hindpaw cortex in mouse. Annual Meeting of the Society for Neuroscience, Washington, DC.
5. Lopez-Valdes HE, Clarkson AN, Carmichael ST, Charles AC, Brennan K (2009). Chronic treatment with memantine enhances recovery of somatosensory maps in a mouse stroke model. Annual Meeting of the Society for Neuroscience, Chicago, IL.
6. Chang J, Shook L, Charles AC, Brennan K (2008). Significant hemoglobin desaturation during cortical spreading depression. 133rd Annual Meeting of the American Neurological Association, Salt Lake City UT.
7. Brennan KC, Chang J, Shook L, Biag J, Nguyen E, Toga AW, Charles AC (2009). Biphasic DC shift, hemoglobin desaturation, and neurovascular uncoupling in cortical spreading depression. 134th Annual Meeting of the American Neurological Association, Baltimore MD. Selected for Platform Presentation.
8. KC Brennan, Jeremy Theriot, Kevin Cury, Arthur W. Toga, Andrew C. Charles (2005). Changes in arterial caliber can precede cortical spreading depression. 12th Annual Congress of the International Headache Society, Kyoto, Japan. Selected for Platform Presentation.
9. KC Brennan, Ying Xu, Louis Ptácek, and Andrew Charle (2006). Reduced threshold for cortical spreading depression in mice expressing CK1dT44A. Channels, Receptors, and Synapses Meeting. Cold Spring Harbor NY. Selected for Platform Presentation.
10. KC Brennan, Robert Shapiro, Louis Ptácek, and Andrew Charle (2006). Reduced threshold for cortical spreading depression and increased vasodilatation in mice expressing CK1dT44A. American Headache Society Annual Scientific Meeting, Los Angeles CA. Selected for Platform Presentation.
11. K.C. Brennan, Hector E. López-Valdés, Marcela Romero Reyes, Arthur P Arnold, Andrew C. Charles (2007). Reduced threshold for cortical spreading depression in female mice. American Headache Society Annual Scientific Meeting, Chicago IL. Selected for Platform Presentation.

Other

1. Brennan K, Digre K, Baggaley (2012). Headache- A Patient's Guide.

News

• Study Reveals Unexpected Protective Role for Brain Swelling After Injury
• Unexpected Discovery Leads to Better Understanding of Migraine
• University of Utah Health Announces Fred W. & Christine A. Fairclough Endowed Chair in Neurology
• One Bad Gene: Mutation that Causes Rare Sleep Disorder Linked to Migraines
• Utah’s Newest, Modern Health Center Opens its Doors
• AirMed Is Moving on Up--To Layton!
• $5.4M Javits Award Funds Research into Origins of Migraine

Podcasts

• Chronic Migraines: A Tidal Wave of Activity in the Brain