Satoshi Minoshima
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Satoshi Minoshima, MD, PhD

Languages spoken: English, Japanese

Satoshi Minoshima, M.D., Ph.D. is Professor and Chair in the Department of Radiology and Imaging Sciences at the University of Utah. Dr. Minoshima is a radiologist specialized in Nuclear Medicine and Molecular Imaging. His scientific contributions in the field of Neuroscience include the discovery of very early sign of Alzheimer's disease in the posterior cingulate cortex and worldwide dissemination of diagnostic statistical mapping technology. He has published over 170 peer reviewed articles and numerous book chapters, review articles, proceedings, and abstracts, and given over 300 presentations. He served as the President of the Brain Imaging Council for the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and currently serves as the SNMMI Chair of the Scientific Program Committee, SNMMI Vice President Elect, as well as the Chair of the Molecular Imaging Committee for the Radiological Society of North America (RSNA). He also works with the United Nations / International Atomic Energy Agency to advance the peaceful use of nuclear technology in medicine. Dr. Minoshima has received multiple awards including Tetalman Memorial Award in 1996 and Kuhl-Lassen Award in 2006 from the SNMMI; Gold Medal from the American Roentgen Ray Society (ARRS) in 2013; Clinical Teaching Award of the Year in 2014; the University of Washington Presidential Entrepreneur Faculty Fellow Award in 2014; and the SNMMI Presidential Distinguished Service Award in 2016.

Specialties

Board Certification

American Board of Nuclear Medicine
Japanese Board of Radiology (Nuclear Medicine)
Federal Licensing Examination
Japanese Board of Radiology (Diagnostic Radiology)
Japanese Board of Radiology (Radiation Oncology)
Educational Commission for Foreign Medical Graduates

Satoshi Minoshima, M.D., Ph.D. is Professor and Chair in the Department of Radiology and Imaging Sciences at the University of Utah. Dr. Minoshima is a radiologist specialized in Nuclear Medicine and Molecular Imaging. His scientific contributions in the field of Neuroscience include the discovery of very early sign of Alzheimer's disease in the posterior cingulate cortex and worldwide dissemination of diagnostic statistical mapping technology. He has published over 170 peer reviewed articles and numerous book chapters, review articles, proceedings, and abstracts, and given over 300 presentations. He served as the President of the Brain Imaging Council for the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and currently serves as the SNMMI Chair of the Scientific Program Committee, SNMMI Vice President Elect, as well as the Chair of the Molecular Imaging Committee for the Radiological Society of North America (RSNA). He also works with the United Nations / International Atomic Energy Agency to advance the peaceful use of nuclear technology in medicine. Dr. Minoshima has received multiple awards including Tetalman Memorial Award in 1996 and Kuhl-Lassen Award in 2006 from the SNMMI; Gold Medal from the American Roentgen Ray Society (ARRS) in 2013; Clinical Teaching Award of the Year in 2014; the University of Washington Presidential Entrepreneur Faculty Fellow Award in 2014; and the SNMMI Presidential Distinguished Service Award in 2016.

Board Certification and Academic Information

Academic Departments Radiology & Imaging Sciences -Professor
Board Certification
American Board of Nuclear Medicine
Japanese Board of Radiology (Nuclear Medicine)
Federal Licensing Examination
Japanese Board of Radiology (Diagnostic Radiology)
Japanese Board of Radiology (Radiation Oncology)
Educational Commission for Foreign Medical Graduates

Education history

Professional Medical Medicine - Chiba University School of Medicine M.D.
Residency Radiology - Chiba University Hospital Resident
Doctoral Training Radiological Science - Chiba University School of Medicine Ph.D.
Postdoctoral Fellowship Nuclear Medicine - University of Michigan Postdoctoral Fellow

Selected Publications

Journal Article

  1. Cross DJ, Flexman JA, Anzai Y, Sasaki T, Treuting PM, Maravilla KR, Minoshima (2007). In vivo manganese MR imaging of calcium influx in spontaneous rat pituitary adenoma. AJNR. American journal of neuroradiology, 28(10), 1865-71.
  2. Minoshima S, Cross DJ, Foster NL, Henry TR, Kuhl D (1999). Discordance between traditional pathologic and energy metabolic changes in very early Alzheimer's disease. Pathophysiological implications. Annals of the New York Academy of Sciences, 893, 350-2.
  3. Kuhl DE, Minoshima S, Fessler JA, Frey KA, Foster NL, Ficaro EP, Wieland DM, Koeppe R (1996). In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease. Annals of neurology, 40(3), 399-410.
  4. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl D (1997). Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Annals of neurology, 42(1), 85-94.
  5. Kuhl DE, Minoshima S, Frey KA, Foster NL, Kilbourn MR, Koeppe R (2000). Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex. Annals of neurology, 48(3), 391-5.
  6. Minoshima S, Foster NL, Sima AA, Frey KA, Albin RL, Kuhl D (2001). Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Annals of neurology, 50(3), 358-65.
  7. Kuhl DE, Koeppe RA, Snyder SE, Minoshima S, Frey KA, Kilbourn M (2006). In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses. Annals of neurology, 59(1), 13-20.
  8. Petrie EC, Cross DJ, Galasko D, Schellenberg GD, Raskind MA, Peskind ER, Minoshima (2009). Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings. Archives of neurology, 66(5), 632-7.
  9. Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A, Arbuckle M, Callaghan M, Tsai E, Plymate SR, Green PS, Leverenz J, Cross D, Gerton (2012). Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Archives of neurology, 69(1), 29-38.
  10. Lorenz J, Cross DJ, Minoshima S, Morrow TJ, Paulson PE, Casey K (2002). A unique representation of heat allodynia in the human brain. Neuron, 35(2), 383-93.
  11. Foster NL, Heidebrink JL, Clark CM, Jagust WJ, Arnold SE, Barbas NR, DeCarli CS, Turner RS, Koeppe RA, Higdon R, Minoshima (2007). FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease. Brain, 130(Pt 10), 2616-35.
  12. Mitsumori LM, McDonald ES, Wilson GJ, Neligan PC, Minoshima S, Maki J (2015). MR lymphangiography: How i do it. Journal of magnetic resonance imaging, 42(6), 1465-77.
  13. Matesan MC, Cross DJ, Lewis DH, Minoshima (2015). Differential alterations of dopamine transporter in the striatum and midbrain in patients with parkinsonian syndrome. Clinical nuclear medicine, 40(3), 191-4.
  14. Casey KL, Lorenz J, Minoshima (2003). Insights into the pathophysiology of neuropathic pain through functional brain imaging. Experimental neurology, 184 Suppl 1, S80-8.
  15. Ladabaum U, Minoshima S, Hasler WL, Cross D, Chey WD, Owyang (2001). Gastric distention correlates with activation of multiple cortical and subcortical regions. Gastroenterology, 120(2), 369-76.
  16. Frey KA, Minoshima S, Koeppe RA, Kilbourn MR, Berger KL, Kuhl D (1996). Stereotaxic summation analysis of human cerebral benzodiazepine binding maps. Journal of cerebral blood flow and metabolism, 16(3), 409-17.
  17. Casey KL, Minoshima S, Berger KL, Koeppe RA, Morrow TJ, Frey K (1994). Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli. Journal of neurophysiology, 71(2), 802-7.
  18. Casey KL, Minoshima S, Morrow TJ, Koeppe R (1996). Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain. Journal of neurophysiology, 76(1), 571-81.
  19. Casey KL, Svensson P, Morrow TJ, Raz J, Jone C, Minoshima (2000). Selective opiate modulation of nociceptive processing in the human brain. Journal of neurophysiology, 84(1), 525-33.
  20. Casey KL, Morrow TJ, Lorenz J, Minoshima (2001). Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography. Journal of neurophysiology, 85(2), 951-9.
  21. Minoshima S, Berger KL, Lee KS, Mintun M (1992). An automated method for rotational correction and centering of three-dimensional functional brain images. Journal of nuclear medicine, 33(8), 1579-85.
  22. Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl D (1995). A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. Journal of nuclear medicine, 36(7), 1238-48.
  23. Minoshima S, Koeppe RA, Frey KA, Kuhl D (1994). Anatomic standardization: linear scaling and nonlinear warping of functional brain images. Journal of nuclear medicine, 35(9), 1528-37.
  24. Minoshima S, Koeppe RA, Mintun MA, Berger KL, Taylor SF, Frey KA, Kuhl D (1993). Automated detection of the intercommissural line for stereotactic localization of functional brain images. Journal of nuclear medicine, 34(2), 322-9.
  25. Vander Borght T, Minoshima S, Giordani B, Foster NL, Frey KA, Berent S, Albin RL, Koeppe RA, Kuhl D (1997). Cerebral metabolic differences in Parkinson's and Alzheimer's diseases matched for dementia severity. Journal of nuclear medicine, 38(5), 797-802.
  26. Bartenstein P, Minoshima S, Hirsch C, Buch K, Willoch F, Mosch D, Schad D, Schwaiger M, Kurz (1997). Quantitative assessment of cerebral blood flow in patients with Alzheimer's disease by SPECT. Journal of nuclear medicine, 38(7), 1095-101.
  27. Drzezga A, Arnold S, Minoshima S, Noachtar S, Szecsi J, Winkler P, Romer W, Tatsch K, Weber W, Bartenstein (1999). 18F-FDG PET studies in patients with extratemporal and temporal epilepsy: evaluation of an observer-independent analysis. Journal of nuclear medicine, 40(5), 737-46.
  28. Drzezga A, Grimmer T, Riemenschneider M, Lautenschlager N, Siebner H, Alexopoulus P, Minoshima S, Schwaiger M, Kurz (2005). Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET. Journal of nuclear medicine, 46(10), 1625-32.
  29. Mosconi L, Tsui WH, Pupi A, De Santi S, Drzezga A, Minoshima S, de Leon M (2007). (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals improves detection of mild cognitive impairment and Alzheimer's disease. Journal of nuclear medicine, 48(7), 1129-34.
  30. Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, Reiman EM, Holthoff V, Kalbe E, Sorbi S, Diehl-Schmid J, Perneczky R, Clerici F, Caselli R, Beuthien-Baumann B, Kurz A, Minoshima S, de Leon M (2008). Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. Journal of nuclear medicine, 49(3), 390-8.
  31. Bohnen NI, Koeppe RA, Minoshima S, Giordani B, Albin RL, Frey KA, Kuhl D (2011). Cerebral glucose metabolic features of Parkinson disease and incident dementia: longitudinal study. Journal of nuclear medicine, 52(6), 848-55.
  32. Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Carrillo MC, Hartley DM, Hedrick S, Pappas V, Thies W (2013). Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association. Journal of nuclear medicine, 54(3), 476-90.
  33. Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Hedrick S, Pappas V, Carrillo MC, Hartley D (2013). Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education. Journal of nuclear medicine, 54(7), 1011-3.
  34. Cross DJ, Anzai Y, Petrie EC, Martin N, Richards TL, Maravilla KR, Peskind ER, Minoshima (2013). Loss of olfactory tract integrity affects cortical metabolism in the brain and olfactory regions in aging and mild cognitive impairment. Journal of nuclear medicine, 54(8), 1278-84.
  35. Sham JG, Kievit FM, Grierson JR, Miyaoka RS, Yeh MM, Zhang M, Yeung RS, Minoshima S, Park J (2014). Glypican-3-targeted 89Zr PET imaging of hepatocellular carcinoma. Journal of nuclear medicine, 55(5), 799-804.
  36. Drzezga A, Barthel H, Minoshima S, Sabri (2014). Potential Clinical Applications of PET/MR Imaging in Neurodegenerative Diseases. Journal of nuclear medicine, 55(Supplement 2), 47S-55S.
  37. Sham JG, Kievit FM, Grierson JR, Chiarelli PA, Miyaoka RS, Zhang M, Yeung RS, Minoshima S, Park J (2014). Glypican-3-targeting F(ab')2 for 89Zr PET of hepatocellular carcinoma. Journal of nuclear medicine, 55(12), 2032-7.
  38. Minoshima S, Foster NL, Kuhl D (1994). Posterior cingulate cortex in Alzheimer's disease. Lancet (London, England), 344(8926), 895.
  39. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne (1996). Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. The New England journal of medicine, 334(12), 752-8.
  40. Jonides J, Smith EE, Koeppe RA, Awh E, Minoshima S, Mintun M (1993). Spatial working memory in humans as revealed by PET. Nature, 363(6430), 623-5.
  41. Albin RL, Minoshima S, D'Amato CJ, Frey KA, Kuhl DA, Sima A (1996). Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology, 47(2), 462-6.
  42. Bohnen NI, Minoshima S, Giordani B, Frey KA, Kuhl D (1999). Motor correlates of occipital glucose hypometabolism in Parkinson's disease without dementia. Neurology, 52(3), 541-6.
  43. Kuhl DE, Koeppe RA, Minoshima S, Snyder SE, Ficaro EP, Foster NL, Frey KA, Kilbourn M (1999). In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology, 52(4), 691-9.
  44. Drzezga A, Riemenschneider M, Strassner B, Grimmer T, Peller M, Knoll A, Wagenpfeil S, Minoshima S, Schwaiger M, Kurz (2005). Cerebral glucose metabolism in patients with AD and different APOE genotypes. Neurology, 64(1), 102-7.
  45. Casey KL, Geisser M, Lorenz J, Morrow TJ, Paulson P, Minoshima (2012). Psychophysical and cerebral responses to heat stimulation in patients with central pain, painless central sensory loss, and in healthy persons. Pain, 153(2), 331-41.
  46. Burdette JH, Minoshima S, Vander Borght T, Tran DD, Kuhl D (1996). Alzheimer disease: improved visual interpretation of PET images by using three-dimensional stereotaxic surface projections. Radiology, 198(3), 837-43.
  47. Anzai Y, Carroll WR, Quint DJ, Bradford CR, Minoshima S, Wolf GT, Wahl R (1996). Recurrence of head and neck cancer after surgery or irradiation: prospective comparison of 2-deoxy-2-[F-18]fluoro-D-glucose PET and MR imaging diagnoses. Radiology, 200(1), 135-41.
  48. Anzai Y, Minoshima S, Wolf GT, Wahl R (1999). Head and neck cancer: detection of recurrence with three-dimensional principal components analysis at dynamic FDG PET. Radiology, 212(1), 285-90.
  49. Dighe M, Bae U, Richardson ML, Dubinsky TJ, Minoshima S, Kim (2008). Differential diagnosis of thyroid nodules with US elastography using carotid artery pulsation. Radiology, 248(2), 662-9.
  50. Cross DJ, Minoshima S, Anzai Y, Flexman JA, Keogh BP, Kim Y, Maravilla K (2004). Statistical mapping of functional olfactory connections of the rat brain in vivo. NeuroImage, 23(4), 1326-35.
  51. Cross DJ, Flexman JA, Anzai Y, Morrow TJ, Maravilla KR, Minoshima (2006). In vivo imaging of functional disruption, recovery and alteration in rat olfactory circuitry after lesion. NeuroImage, 32(3), 1265-72.
  52. Cross DJ, Flexman JA, Anzai Y, Maravilla KR, Minoshima (2008). Age-related decrease in axonal transport measured by MR imaging in vivo. NeuroImage, 39(3), 915-26.
  53. Peskind ER, Petrie EC, Cross DJ, Pagulayan K, McCraw K, Hoff D, Hart K, Yu CE, Raskind MA, Cook DG, Minoshima (2011). Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms. NeuroImage, 54 Suppl 1, S76-82.
  54. Flexman JA, Minoshima S, Kim Y, Miyoshi S, Lewellen BL, Cross D (2006). A viral envelope as a vehicle for tracer, drug, and gene delivery. IEEE engineering in medicine and biology magazine, 25(4), 70-5.
  55. Smith EE, Jonides J, Koeppe RA, Awh E, Schumacher EH, Minoshima (1995). Spatial versus Object Working Memory: PET Investigations. Journal of cognitive neuroscience, 7(3), 337-56.
  56. Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, Schwaiger M, Kurz (2003). Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. European journal of nuclear medicine and molecular imaging, 30(8), 1104-13.
  57. Flexman JA, Cross DJ, Tran LN, Sasaki T, Kim Y, Minoshima (2011). Quantitative analysis of neural stem cell migration and tracer clearance in the rat brain by MRI. Molecular imaging and biology, 13(1), 104-11.
  58. Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Carrillo MC, Hartley DM, Hedrick S, Pappas V, Thies W (2013). Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association. Alzheimer's & dementia, 9(1), e-1-16.
  59. Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Hedrick S, Pappas V, Carrillo MC, Hartley D (2013). Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education. Amyloid Imaging Task Force of the Alzheimer's Association and Society for Nuclear Medicine and Molecular Imaging. Alzheimer's & dementia, 9(4), e106-9.
  60. Meabon JS, Huber BR, Cross DJ, Richards TL, Minoshima S, Pagulayan KF, Li G, Meeker KD, Kraemer BC, Petrie EC, Raskind MA, Peskind ER, Cook D (2016). Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction. Science translational medicine, 8(321), 321ra6.

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