Why Choose Us for Cancers of Unknown Primary Origin Care
At Huntsman Cancer Institute, you receive specialized, multidisciplinary care for cancers of unknown primary origin (CUP). As a National Cancer Institute-designated Comprehensive Cancer Center, we combine deep experience, advanced diagnostics, and access to clinical trials to deliver hope in even the most challenging cases.
We work with you to create a comprehensive treatment plan focused on your needs and goals. Our approach balances evidence-backed research with preservation of function to help you maintain your quality of life.
“The staff at Huntsman Cancer Institute are the very best, and I give them an 11 out of 10."
—Huntsman Cancer Institute Patient
Treatments We Offer
When the primary tumor can’t be found, we tailor treatment based on your tumor type, location, and condition. These are some common options:
Our Expertise
As the National Cancer Institute-designated Comprehensive Cancer Center serving the Mountain West, we’re here to offer you the latest treatments and the highest level of care available, including expertise in the following:
- Individualized treatment plans for rare and complex cases of CUP
- Multidisciplinary tumor boards that review every case
- Cutting-edge molecular diagnostics to guide therapy
Patient Care Philosophy
We believe no one should face cancer alone. Our dedicated and world-renowned doctors, nurses, and medical staff are at the forefront of patient-centered care. We treat the whole person, not just their cancer.
Each day, our medical, surgical, and radiation oncologists work together across disciplines to create and coordinate treatment plans for every patient. We understand cancer is a complex disease. That is why we use a team approach that includes social workers and support groups, as well as wellness and integrative health services such as acupuncture, massage, creative arts, and more.
Cancers of Unknown Primary Origin Research
Researchers at Huntsman Cancer Institute are dedicated to improving outcomes for people with cancers of unknown primary origin. Through innovative research and clinical trials, we explore new diagnostics, therapies, and supportive care strategies to provide more effective options for this complex diagnosis.
With the largest Phase 1 clinical trials program offering cancer care in the Mountain West, we offer access to cutting-edge treatments, often before they are available anywhere else.
Clinical Trials
Make an appointment with a cancer of unknown primary origin specialist
To make an appointment with a cancer of unknown primary origin specialist, fill out our appointment form or call 801-587-7000. Our team will determine if your insurance covers treatment at Huntsman Cancer Institute or if you need a referral from a primary care doctor.
External providers can refer a patient using the online referral form or by calling 801-587-7000 to speak to a patient registration specialist.
Cancers of Unknown Primary Origin Basics
Cancers of unknown primary origin (CUP) are rare diseases in which the site of your cancer’s origin cannot be found.
Symptoms can vary widely depending on the site of spread (e.g., lymph nodes, liver, bones). These may be warning signs of cancers of unknown primary origin:
- Swollen, firm, non-tender lymph nodes
- A mass in the abdomen (belly) that can be felt
- Unexplained shortness of breath
- Persistent pain in the chest or abdomen
- Bone pain (common areas include the back, legs, and hips)
- Skin tumors (bumps or patches on the skin)
- Low red blood cell count (anemia)
- Unexplained weakness, fatigue, poor appetite, and weight loss
This is not a complete list of symptoms that can be caused by CUP. Many of these symptoms can be caused by other conditions. If you are experiencing any concerning signs, schedule a screening today.
Doctors may use the following to diagnose cancers of unknown primary origin:
- Physical exam and history
- Imaging (CT/MRI scans)
- Biopsies (tissue sampling)
- Molecular and immunohistochemical tests
Because the origin is unknown, staging emphasizes sites of involvement, extent of spread, and response to treatment.
Need help navigating your care? The Cancer Learning Center is here to support you with personalized guidance, resources, and answers to your questions.
